Rabbit anti-Human CCL27 Polyclonal Antibody | anti-CCL27 antibody

CCL27, CT (CCL27, ILC, SCYA27, C-C motif chemokine 27, CC chemokine ILC, Cutaneous T-cell-attracting chemokine, ESkine, IL-11 R-alpha-locus chemokine, Skinkine, Small-inducible cytokine A27) (PE)

Cat. Num. AAA6282068

• Gene Names: CCL27; ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CCL27; Polyclonal Antibody; CT (CCL27; ILC; SCYA27; C-C motif chemokine 27; CC chemokine ILC; Cutaneous T-cell-attracting chemokine; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27) (PE); Small-inducible cytokine A27; anti-CCL27 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-CCL27 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CCL27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the C-terminal region of human CCL27.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CCL27 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CCL27 antibody detected the CCL27 protein (arrow).)

Related Product Information for anti-CCL27 antibody

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation.

Product Categories/Family for anti-CCL27 antibody

Antibodies; Growth Factors; Cytokines

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009). Narbutt, J., et al. Mediators Inflamm. 2009, 269541 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 5730035
• NCBI GeneID: 10850
• NCBI Accession #: NP_006655.1
• NCBI GenBank Nucleotide #: NM_006664.2
• UniProt Accession #: Q9Y4X3
• Molecular Weight: 12,618 Da
• NCBI Official Full Name: C-C motif chemokine 27
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 27
• NCBI Official Symbol: CCL27
• NCBI Official Synonym Symbols: ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27
• NCBI Protein Information: C-C motif chemokine 27; skinkine; CC chemokine ILC; IL-11 Ralpha-locus chemokine; small-inducible cytokine A27; IL-11 R-alpha-locus chemokine; cutaneous T-cell attracting chemokine; cutaneous T-cell-attracting chemokine; small inducible cytokine subfamily
• UniProt Protein Name: C-C motif chemokine 27
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL27
• UniProt Synonym Gene Names: ILC; SCYA27; CTACK
• UniProt Entry Name: CCL27_HUMAN

NCBI Description

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Jul 2008]

Uniprot Description

CCL27: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; immune response; chemotaxis