Testing Data
(Anti-CCL18 Picoband antibody, MBS176907-1.jpgAll lanes: Anti-CCL18(MBS176907) at 0.5ug/mlWB: Recombinant Human CCL18 Protein 0.5ngPredicted bind size: 19KDObserved bind size: 19KD )
Rabbit anti-Human CCL18 Polyclonal Antibody | anti-CCL18 antibody
Anti-CCL18 antibody
Testing Data
(Anti-CCL18 Picoband antibody, MBS176907-1.jpgAll lanes: Anti-CCL18(MBS176907) at 0.5ug/mlWB: Recombinant Human CCL18 Protein 0.5ngPredicted bind size: 19KDObserved bind size: 19KD )
Testing Data
(Anti-CCL18 Picoband antibody, MBS176907-1.jpgAll lanes: Anti-CCL18(MBS176907) at 0.5ug/mlWB: Recombinant Human CCL18 Protein 0.5ngPredicted bind size: 19KDObserved bind size: 19KD )
Background: Macrophage Inflammatory Protein 4, also known as CCL18, is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). CCL18 is approximately 60% identical in amino acid sequence to CCL3. By analysis of a previously mapped CCL18 from 17q11.2, it is determined that the PARC gene is located within 1 of the 2 clusters of CC chemokine genes in this region. It is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and nonactivated lymphocytes. Beside, CCL18 recruits Th2 cells and basophils and may play a predominant role in allergic asthma.
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
Uniprot Description
CCL18: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular space
Molecular Function: protein binding; chemokine activity
Biological Process: cell-cell signaling; response to biotic stimulus; cell communication; immune response; chemotaxis; signal transduction; inflammatory response
Research Articles on CCL18
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Product Notes
The CCL18 ccl18 (Catalog #AAA176907) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CCL18 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CCL18 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the CCL18 ccl18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCL18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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