Rabbit anti-Human CCK4 Polyclonal Antibody | anti-CCK4 antibody

CCK4, NT (Tyrosine-protein Kinase-like 7, Colon Carcinoma Kinase-4, CCK-4, Protein-tyrosine Kinase 7, PTK7) (AP)

Cat. Num. AAA6468798

• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: CCK4; Polyclonal Antibody; NT (Tyrosine-protein Kinase-like 7; Colon Carcinoma Kinase-4; CCK-4; Protein-tyrosine Kinase 7; PTK7) (AP); anti-CCK4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PTK7.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 1070

• Applicable Applications for anti-CCK4 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the N-terminal region of human PTK7 (KLH).
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-CCK4 antibody

Antibodies; Tyrosine Kinases

References

1. Zhang, H., et al., Nat. Biotechnol. 21(6):660-666 (2003). 2. Park, S.K., et al., J. Biochem. 119(2):235-239 (1996). 3. Mossie, K., et al., Oncogene 11(10):2179-2184 (1995).

NCBI and Uniprot Product Information

• NCBI GI #: 15826840
• NCBI Accession #: NP_002812
• NCBI GenBank Nucleotide #: NP_002812.2
• UniProt Accession #: Q13308
• Molecular Weight: 118.26
• NCBI Official Full Name: inactive tyrosine-protein kinase 7 isoform a
• UniProt Protein Name: Inactive tyrosine-protein kinase 7
• UniProt Gene Name: PTK7
• UniProt Synonym Gene Names: CCK4; CCK-4
• UniProt Entry Name: PTK7_HUMAN

Uniprot Description

CCK4: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; CCK4 family

Chromosomal Location of Human Ortholog: 6p21.1-p12.2

Cellular Component: focal adhesion; integral to plasma membrane; intercellular junction

Molecular Function: protein binding; protein-tyrosine kinase activity; ATP binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; wound healing; convergent extension; actin cytoskeleton reorganization; neural tube closure; establishment of epithelial cell polarity; establishment of planar polarity; Wnt receptor signaling pathway through beta-catenin; cell adhesion; signal transduction