Rabbit anti-Human CCDC6 Polyclonal Antibody | anti-CCDC6 antibody

CCDC6, NT (CCDC6, D10S170, TST1, Coiled-coil domain-containing protein 6, Papillary thyroid carcinoma-encoded protein, Protein H4) (Biotin)

Cat. Num. AAA6281807

• Gene Names: CCDC6; H4; PTC; TPC; TST1; D10S170
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CCDC6; Polyclonal Antibody; NT (CCDC6; D10S170; TST1; Coiled-coil domain-containing protein 6; Papillary thyroid carcinoma-encoded protein; Protein H4) (Biotin); Protein H4; anti-CCDC6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-CCDC6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CCDC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human CCDC6.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CCDC6 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CCDC6 antibody detected the CCDC6 protein (arrow).)

Related Product Information for anti-CCDC6 antibody

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.

Product Categories/Family for anti-CCDC6 antibody

Antibodies; Cancer Markers

References

Leone, V., et al. Oncogene 29(30):4341-4351(2010). Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009). Jazdzewski, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7269-7274(2008). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Olsen, J.V., et al. Cell 127(3):635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 46852390
• NCBI GeneID: 8030
• NCBI Accession #: NP_005427.2
• NCBI GenBank Nucleotide #: NM_005436.4
• UniProt Accession #: Q16204; Q15250; Q6GSG7
• Molecular Weight: 53,291 Da
• NCBI Official Full Name: coiled-coil domain-containing protein 6
• NCBI Official Synonym Full Names: coiled-coil domain containing 6
• NCBI Official Symbol: CCDC6
• NCBI Official Synonym Symbols: H4; PTC; TPC; TST1; D10S170
• NCBI Protein Information: coiled-coil domain-containing protein 6
• UniProt Protein Name: Coiled-coil domain-containing protein 6
• Protein Family: Coiled-coil domain-containing protein
• UniProt Gene Name: CCDC6
• UniProt Synonym Gene Names: D10S170; TST1

NCBI Description

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

Uniprot Description

CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

Protein type: Apoptosis; Cytoskeletal; Oncoprotein

Chromosomal Location of Human Ortholog: 10q21.2

Cellular Component: cytoplasm

Molecular Function: protein binding; structural constituent of cytoskeleton

Disease: Thyroid Carcinoma, Papillary