Rabbit anti-Human CCBL1 Polyclonal Antibody | anti-CCBL1 antibody

CCBL1, CT (CCBL1, Kynurenine-oxoglutarate transaminase 1, Cysteine-S-conjugate beta-lyase, Glutamine transaminase K, Glutamine-phenylpyruvate transaminase, Kynurenine aminotransferase I, Kynurenine-oxoglutarate transaminase I) (PE)

Cat. Num. AAA6281353

• Gene Names: KYAT1; GTK; KAT1; KATI; CCBL1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CCBL1; Polyclonal Antibody; CT (CCBL1; Kynurenine-oxoglutarate transaminase 1; Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; Glutamine-phenylpyruvate transaminase; Kynurenine aminotransferase I; Kynurenine-oxoglutarate transaminase I) (PE); Kynurenine--oxoglutarate transaminase 1; Glutamine--phenylpyruvate transaminase; Kynurenine--oxoglutarate transaminase I; anti-CCBL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-CCBL1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CCBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-355 amino acids from the C-terminal region of human CCBL1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CCBL1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CCBL1 antibody detected the CCBL1 protein (arrow).)

Related Product Information for anti-CCBL1 antibody

This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.

Product Categories/Family for anti-CCBL1 antibody

Antibodies; Enzymes; Aminotransferase

References

Han, Q., et al. J. Med. Chem. 52(9):2786-2793(2009). Cooper, A.J., et al. Arch. Biochem. Biophys. 474(1):72-81(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Kapoor, R., et al. Brain Res. 1106(1):205-210(2006). Cooper, A.J., et al. Amino Acids 30(1):1-15(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 95147551
• NCBI GeneID: 883
• NCBI Accession #: NP_004050.3; NP_001116144.1
• NCBI GenBank Nucleotide #: NM_004059.4
• UniProt Accession #: Q16773; Q5T275; Q8N191
• Molecular Weight: 27,420 Da
• NCBI Official Full Name: kynurenine--oxoglutarate transaminase 1 isoform a
• NCBI Official Synonym Full Names: kynurenine aminotransferase 1
• NCBI Official Symbol: KYAT1
• NCBI Official Synonym Symbols: GTK; KAT1; KATI; CCBL1
• NCBI Protein Information: kynurenine--oxoglutarate transaminase 1
• UniProt Protein Name: Kynurenine--oxoglutarate transaminase 1
• UniProt Gene Name: CCBL1
• UniProt Synonym Gene Names: GTK; KATI
• UniProt Entry Name: KAT1_HUMAN

NCBI Description

This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.6.1.64; EC 2.6.1.7; EC 4.4.1.13; Lyase; Transferase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: glutamine-pyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; phenylalanine(histidine) transaminase activity; protein binding; protein homodimerization activity; transaminase activity

Biological Process: amino acid biosynthetic process; amino acid derivative metabolic process; L-phenylalanine catabolic process; tryptophan catabolic process