Rabbit CCAR1 Polyclonal Antibody | anti-CCAR1 antibody

CCAR1 (Cell Cycle and Apoptosis Regulatory Protein 1) (HRP).

Cat. Num. AAA6445429

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: CCAR1; Polyclonal Antibody; CCAR1 (Cell Cycle and Apoptosis Regulatory Protein 1) (HRP).; anti-CCAR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CCAR1. Species Crossreactivity: Mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-CCAR1 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human CCAR1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Product Categories/Family for anti-CCAR1 antibody

Antibodies; Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 545479138
• NCBI GeneID: 55749
• NCBI Accession #: NP_001269888.1
• NCBI GenBank Nucleotide #: NM_001282959.1
• UniProt Accession #: Q8IX12; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q9H8N4; A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8
• Molecular Weight: 131,043 Da
• NCBI Official Full Name: cell division cycle and apoptosis regulator protein 1 isoform b
• NCBI Official Synonym Full Names: cell division cycle and apoptosis regulator 1
• NCBI Official Symbol: CCAR1
• NCBI Protein Information: cell division cycle and apoptosis regulator protein 1; cell cycle and apoptosis regulatory protein 1; death inducer with SAP domain
• UniProt Protein Name: Cell division cycle and apoptosis regulator protein 1
• Protein Family: Cell division cycle and apoptosis regulator protein
• UniProt Gene Name: CCAR1
• UniProt Synonym Gene Names: CARP1; DIS; CARP-1
• UniProt Entry Name: CCAR1_HUMAN

Uniprot Description

CCAR1: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; RNA splicing; Apoptosis

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: nucleoplasm; perinuclear region of cytoplasm

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; RNA splicing; gene expression; cell cycle