Western Blot (WB)
(Western Blot: Sample: Recombinant CAV1, Mouse.)
Rabbit anti-Mouse Caveolin 1 (CAV1) Polyclonal Antibody | anti-CAV1 antibody
Polyclonal Antibody to Caveolin 1 (CAV1)
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQ GPLGSEF- MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLS
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant CAV1, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant CAV1, Mouse.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 6|6 A2
Cellular Component: acrosomal membrane; apical plasma membrane; basal plasma membrane; basolateral plasma membrane; caveola; cell cortex; cell surface; cilium; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endosome; focal adhesion; Golgi apparatus; Golgi membrane; integral component of membrane; integral component of plasma membrane; intracellular; lipid droplet; membrane; membrane raft; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane; protein complex
Molecular Function: ATPase binding; enzyme binding; identical protein binding; inward rectifier potassium channel inhibitor activity; ion channel binding; kinase binding; nitric-oxide synthase binding; protease activator activity; protein binding; protein binding, bridging; protein complex scaffold activity; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; receptor binding; SNARE binding; structural molecule activity; syntaxin binding
Biological Process: angiogenesis; angiotensin-activated signaling pathway involved in heart process; calcium ion homeostasis; calcium ion transport; caveolin-mediated endocytosis; cellular calcium ion homeostasis; cellular response to exogenous dsRNA; cellular response to hyperoxia; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular senescence; cholesterol efflux; cholesterol homeostasis; endocytosis; inactivation of MAPK activity; lactation; lipid storage; maintenance of cellular protein localization; mammary gland development; mammary gland involution; membrane depolarization; microtubule polymerization; negative regulation of anoikis; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cation channel activity; negative regulation of cell proliferation; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of ERK1 and ERK2 cascade; negative regulation of JAK-STAT cascade; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of muscle cell apoptotic process; negative regulation of neuron differentiation; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine autophosphorylation; negative regulation of pinocytosis; negative regulation of potassium ion transmembrane transport; negative regulation of protein binding; negative regulation of protein ubiquitination; negative regulation of signal transduction; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; nitric oxide homeostasis; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt signaling pathway; positive regulation of catalytic activity; positive regulation of endocytosis; positive regulation of endothelial cell proliferation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of signal transduction; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; posttranscriptional regulation of gene expression; protein homooligomerization; protein localization; protein oligomerization; receptor internalization; receptor internalization involved in canonical Wnt signaling pathway; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of cytosolic calcium ion concentration; regulation of entry of bacterium into host cell; regulation of fatty acid metabolic process; regulation of heart rate by cardiac conduction; regulation of membrane repolarization during action potential; regulation of peptidase activity; regulation of ruffle assembly; regulation of smooth muscle contraction; regulation of the force of heart contraction; regulation of the force of heart contraction by chemical signal; regulation of ventricular cardiac muscle cell action potential; response to bacterium; response to calcium ion; response to estrogen; response to hypoxia; response to mechanical stimulus; response to progesterone; skeletal muscle tissue development; T cell costimulation; triacylglycerol metabolic process; vasculogenesis; vasoconstriction; wound healing
Research Articles on CAV1
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Product Notes
The CAV1 cav1 (Catalog #AAA2002976) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Caveolin 1 (CAV1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Caveolin 1 (CAV1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CAV1 cav1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQ GPLGSEF- MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADEVTEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLS. It is sometimes possible for the material contained within the vial of "Caveolin 1 (CAV1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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