Rabbit Cathepsin L2 Polyclonal Antibody | anti-L114 antibody

Cathepsin L2 (L114) Polyclonal Antibody

Cat. Num. AAA3008409

• Gene Names: CTSV; CTSU; CATL2; CTSL2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Cathepsin L2; Polyclonal Antibody; Cathepsin L2 (L114) Polyclonal Antibody; Cathepsin U; Cathepsin V; CTSV; CATL2; CTSL2; CTSU; UNQ268; PRO305; anti-L114 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Cathepsin L2 (L114) polyclonal antibody detects endogenous levels of Cathepsin L2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 334

• Applicable Applications for anti-L114 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 91-140 of Human Cathepsin L2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Cathepsin L2 (L114) pAb at 1:1000 dilutionLane1:The Testis tissue lysate of Mouse (40ug) Lane2:The Testis tissue lysate of Rat (40ug) Lane3:L02 whole cell lysate (20ug) Lane4:A375 whole cell lysate (20ug))

Related Product Information for anti-L114 antibody

Cathepsin V (CTSU, CTSV, CATL2, cathepsin U, cathepsin L2) is a lysosomal cysteine proteinase that influences corneal physiology, and mediates degradation of invariant chain in human thymus. Cathepsin V is present in corneal epithelium, activated macrophages, and colorectal and breast carcinomas. A 1.8-kb mRNA to Cathepsin V is present in normal human thymus and testis. Cathepsin V is a member of the peptidase C1 family. Cysteine proteinases are synthesized as preproenzymes, which are processed to the corresponding proenzymes. The proenzymes are either targeted to the lysosome or continue along the cellular secretory route.

NCBI and Uniprot Product Information

• NCBI GI #: 320118898
• NCBI GeneID: 1515
• NCBI Accession #: NP_001188504.1
• NCBI GenBank Nucleotide #: NP_001188504.1
• UniProt Accession #: O60911
• Molecular Weight: ~ 37kDa
• NCBI Official Full Name: cathepsin L2 preproprotein
• NCBI Official Synonym Full Names: cathepsin V
• NCBI Official Symbol: CTSV
• NCBI Official Synonym Symbols: CTSU; CATL2; CTSL2
• NCBI Protein Information: cathepsin L2
• UniProt Protein Name: Cathepsin L2
• Protein Family: Cathepsin
• UniProt Gene Name: CTSL2
• UniProt Synonym Gene Names: CATL2; CTSU; CTSV
• UniProt Entry Name: CATL2_HUMAN

NCBI Description

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

Uniprot Description

CTSL2: Cysteine protease. May have an important role in corneal physiology. Belongs to the peptidase C1 family.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.22.15

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: extracellular space; lysosomal lumen; neuron projection; microvillus; apical part of cell; extracellular region; nucleolus; perikaryon; secretory granule; external side of plasma membrane

Molecular Function: protein binding; histone binding; cysteine-type endopeptidase activity; protein complex binding; aminopeptidase activity; kininogen binding; cysteine-type carboxypeptidase activity; peptide binding; cysteine-type peptidase activity

Biological Process: extracellular matrix organization and biogenesis; hair follicle morphogenesis; response to glucocorticoid stimulus; Sertoli cell differentiation; multicellular organismal aging; antigen processing and presentation of exogenous peptide antigen via MHC class II; decidualization; proteolysis; cellular response to starvation; extracellular matrix disassembly; protein autoprocessing; response to glucose stimulus; autophagic cell death; nerve development; spermatogenesis