Rabbit anti-Human CTSL2 Polyclonal Antibody | anti-CTSV antibody

CTSL2, ID (Cathepsin V, Cathepsin L2, Cathepsin U, Cathepsin V, CATL2, CTSU, CTSV, UNQ268/PRO305)

Cat. Num. AAA649451

• Gene Names: CTSV; CTSU; CATL2; CTSL2
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CTSL2; Polyclonal Antibody; ID (Cathepsin V; Cathepsin L2; Cathepsin U; Cathepsin V; CATL2; CTSU; CTSV; UNQ268/PRO305); Anti -CTSL2; anti-CTSV antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CTSL2.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-CTSV antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: ELISA: 1:20,000; Western Blot: 1:500-1:1000; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to human CATL2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of extracts from 293/COS cells, treated with etoposide 25uM 1h, using CATL2 (Cleaved-Leu114) Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-CTSV antibody

Cathepsin V, also known as Cathepsin L2 and Cathepsin U, is a cysteine protease of the papain family. It is expressed as a proenzyme in lysosomes, which can be autocatalytically converted to the mature form at pH 4.0. Cathepsin V is specifically expressed in the thymus, testis, and corneal epithelium.

Product Categories/Family for anti-CTSV antibody

Antibodies; Abs to Cathepsin

NCBI and Uniprot Product Information

• NCBI GI #: 320118898
• NCBI GeneID: 1515
• NCBI Accession #: NP_001188504.1
• NCBI GenBank Nucleotide #: NM_001201575.1
• UniProt Accession #: O60911; O60233; Q2TB86; Q5T1U0
• Molecular Weight: 37,329 Da
• NCBI Official Full Name: cathepsin L2 preproprotein
• NCBI Official Synonym Full Names: cathepsin V
• NCBI Official Symbol: CTSV
• NCBI Official Synonym Symbols: CTSU; CATL2; CTSL2
• NCBI Protein Information: cathepsin L2; cathepsin U; cathepsin L2, preproprotein
• UniProt Protein Name: Cathepsin L2
• UniProt Gene Name: CTSV
• UniProt Synonym Gene Names: CATL2; CTSL2; CTSU
• UniProt Entry Name: CATL2_HUMAN

NCBI Description

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

Uniprot Description

Function: Cysteine protease. May have an important role in corneal physiology. Ref.2 Ref.3

Catalytic activity: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Ref.3

Subcellular location: Lysosome

Potential.

Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. Ref.1 Ref.2 Ref.3

Sequence similarities: Belongs to the peptidase C1 family.