Rabbit Cathepsin K Polyclonal Antibody | anti-Ctsk antibody

Cathepsin K Antibody

Cat. Num. AAA840547

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: Cathepsin K; Polyclonal Antibody; Cathepsin K Antibody; CTSK; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; anti-Ctsk antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.5 mg/ml) Protein A purified rabbit anti-cathepsin K polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 329

• Applicable Applications for anti-Ctsk antibody: Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Application Notes: Western blotting (0.5-4 ug/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. Detects 43 kDa cathepsin K of human, mouse, and rat origin.
• Immunogen: Synthetic peptide surrounding amino acid 321 of rat cathepsin K
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-Ctsk antibody

Background: Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin K expression is highest in bone, cartilage, and skeletal muscle

NCBI and Uniprot Product Information

• NCBI GI #: 13928758
• NCBI GeneID: 29175
• NCBI Accession #: NP_113748
• NCBI GenBank Nucleotide #: NM_031560.2
• Molecular Weight: 36,791 Da
• NCBI Official Full Name: cathepsin K
• NCBI Official Synonym Full Names: cathepsin K
• NCBI Official Symbol: Ctsk
• NCBI Protein Information: cathepsin K
• UniProt Protein Name: Cathepsin K
• Protein Family: Cathepsin
• UniProt Gene Name: Ctsk
• UniProt Entry Name: CATK_RAT

NCBI Description

putative protease; human homolog displays endoprotease activity and is associated with pycnodysostosis when mutated [RGD, Feb 2006]

Uniprot Description

CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.38; Protease

Cellular Component: extracellular space; lysosome; cytoplasm

Molecular Function: collagen binding; proteoglycan binding; cysteine-type endopeptidase activity; fibronectin binding; cysteine-type peptidase activity

Biological Process: collagen catabolic process; intramembranous ossification; proteolysis involved in cellular protein catabolic process; proteolysis; bone resorption