Rabbit Cathepsin D Polyclonal Antibody | anti-CPSD antibody

Cathepsin D Antibody

Cat. Num. AAA5314236

• Gene Names: CTSD; CPSD; CLN10; HEL-S-130P
• Applications: Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: Immunogen Affinity Chromatography
• Synonyms: Cathepsin D; Polyclonal Antibody; Cathepsin D Antibody; Purified Polyclonal Cathepsin D Antibody; Polyclonal Cathepsin D antibody; Anti-Cathepsin D antibody; CPSD antibody; Cathepsin D antibody; anti-CPSD antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of Cathepsin D protein
• Purity/Purification: Immunogen Affinity Chromatography
• Form/Format: Supplied in liquid form in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3 with 30% Glycerol and 0.01% Sodium Azide
• Sequence Length: 412

• Applicable Applications for anti-CPSD antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Application Notes: WB: 1:500-1:1000; IHC: 1:100-1:200; IP: 1:10-1:100
• Immunogen: Cathepsin D antibody was raised in Rabbit using a KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin D as the immunogen
• Cross-Reactivity: Monkey
• Preparation and Storage: Store at 4 degree C for short term storage. For long term, aliquot and store at -20 degree C. Avoid repeat freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of Cathepsin D expression in HepG2 (A); MDAMB231 (B); MCF7 (C) whole cell lysates.)

Related Product Information for anti-CPSD antibody

Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor.

Product Categories/Family for anti-CPSD antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 4503143
• NCBI GeneID: 1509
• NCBI GenBank Nucleotide #: NP_001900.1
• UniProt Accession #: P07339
• NCBI Official Full Name: cathepsin D preproprotein
• NCBI Official Synonym Full Names: cathepsin D
• NCBI Official Symbol: CTSD
• NCBI Official Synonym Symbols: CPSD; CLN10; HEL-S-130P
• NCBI Protein Information: cathepsin D
• UniProt Protein Name: Cathepsin D
• Protein Family: Cathepsin
• UniProt Gene Name: CTSD
• UniProt Synonym Gene Names: CPSD
• UniProt Entry Name: CATD_HUMAN

NCBI Description

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

Uniprot Description

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: Protease; Autophagy; EC 3.4.23.5; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; lysosome; melanosome; extracellular region

Molecular Function: protein binding; aspartic-type endopeptidase activity

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10