Rabbit anti-Human, Mouse CARD11 Polyclonal Antibody | anti-CARD11 antibody

Rabbit anti CARD11

Cat. Num. AAA225088

• Gene Names: CARD11; PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified whole serum by affinity chromatography.
• Synonyms: CARD11; Polyclonal Antibody; Rabbit anti CARD11; CARD11 Antibody; anti-CARD11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified whole serum by affinity chromatography.
• Form/Format: Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
• Sequence Length: 1154

• Applicable Applications for anti-CARD11 antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-Paraffin: 1:50-1:200; WB: 1:500-1:2000
• Immunogen: Recombinant human CARD11
• Preperation: Antiserum to CARD11 was raised by repeated immunization of rabbits with highly purified antigen.
• Preparation and Storage: Store at -20 degree C.; Storage in frost-free freezers is not recommended. This product should be stored undiluted.; Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch

Western Blot (WB)

(Western blot analysis of Raji cell lysate and mouse tissue lysate using Rabbit anti CARD11 antibody)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver injury using Rabbit anti CARD11 antibody at a dilution of 1/100)

Related Product Information for anti-CARD11 antibody

Rabbit anti CARD11 antibody recognizes caspase recruitment domain-containing protein 11 (CARD11), also known as CARMA1. CARD11 is part of both the membrane associated guanylate kinase (MAGUK) family and the caspase recruitment domain (CARD) family. CARD11 is involved in NF-KappaB activation through interaction with signaling protein BCL10.

NCBI and Uniprot Product Information

• NCBI GI #: 172046231
• NCBI GeneID: 84433
• UniProt Accession #: Q9BXL7; Q2NKN7; Q548H3; A4D1Z7
• Molecular Weight: 133,284 Da
• NCBI Official Full Name: Caspase recruitment domain-containing protein 11
• NCBI Official Synonym Full Names: caspase recruitment domain family member 11
• NCBI Official Symbol: CARD11
• NCBI Official Synonym Symbols: PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A
• NCBI Protein Information: caspase recruitment domain-containing protein 11
• UniProt Protein Name: Caspase recruitment domain-containing protein 11
• Protein Family: Caspase recruitment domain-containing protein
• UniProt Gene Name: CARD11
• UniProt Synonym Gene Names: Carma 1

NCBI Description

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.