Rabbit CANT1 Polyclonal Antibody | anti-CANT1 antibody

CANT1 Polyclonal Antibody

Cat. Num. AAA2562417

• Gene Names: CANT1; DBQD; EDM7; DBQD1; SCAN1; SHAPY; SCAN-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: CANT1; Polyclonal Antibody; CANT1 Polyclonal Antibody; Apyrase; Apyrase homolog; Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase; Calcium activated nucleotidase 1; CANT 1; Putative MAPK activating protein PM09; Putative MAPK-activating protein PM09; Putative NF kappa B activating protein 107; Putative NF-kappa-B-activating protein 107; SCAN 1; SCAN-1; SHAPY; Soluble Ca activated nucleotidase isozyme 1; Soluble calcium activated nucleotidase 1; Soluble calcium activated nucleotidase SCAN 1; Soluble calcium-activated nucleotidase 1; anti-CANT1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.7mg/mL (varies by lot)
• Sequence Length: 401

• Applicable Applications for anti-CANT1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human CANT1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of Hela and A375 cell lysates using CANT1 Polyclonal Antibody at dilution of 1:500)

Related Product Information for anti-CANT1 antibody

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.

Product Categories/Family for anti-CANT1 antibody

Epigenetics and Nuclear Signaling; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 229577440
• NCBI GeneID: 124583
• NCBI Accession #: NP_001153244.1; BC017655
• NCBI GenBank Nucleotide #: NP_001153244.1
• UniProt Accession #: Q8WVQ1
• Molecular Weight: 45 kDa
• NCBI Official Full Name: soluble calcium-activated nucleotidase 1
• NCBI Official Synonym Full Names: calcium activated nucleotidase 1
• NCBI Official Symbol: CANT1
• NCBI Official Synonym Symbols: DBQD; EDM7; DBQD1; SCAN1; SHAPY; SCAN-1
• NCBI Protein Information: soluble calcium-activated nucleotidase 1
• UniProt Protein Name: Soluble calcium-activated nucleotidase 1
• Protein Family: Soluble calcium-activated nucleotidase
• UniProt Gene Name: CANT1
• UniProt Synonym Gene Names: SHAPY; SCAN-1
• UniProt Entry Name: CANT1_HUMAN

NCBI Description

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]

Uniprot Description

CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Endoplasmic reticulum; Membrane protein, integral; EC 3.6.1.6

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: signal transducer activity; calcium ion binding; uridine-diphosphatase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process; signal transduction

Disease: Desbuquois Dysplasia 1