Rabbit anti-Human ATAD3A Polyclonal Antibody | anti-ATAD3A antibody

ATAD3A Antibody (N-term)

Cat. Num. AAA9231895

• Gene Names: ATAD3A; HAYOS
• Reactivity: Human
• Applications: Western Blot, ELISA
• Synonyms: ATAD3A; Polyclonal Antibody; ATAD3A Antibody (N-term); ATPase family AAA domain-containing protein 3A; anti-ATAD3A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This ATAD3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-48 amino acids from the N-terminal region of human ATAD3A.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 634

• Applicable Applications for anti-ATAD3A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000
• Antigen Source: Human
• Antigen Region: 24-48
• Antigen Type: Synthetic Peptide
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of lysates from NCI-H292,A549 cell line (from left to right), using ATAD3A Antibody (N-term). It was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.)

Related Product Information for anti-ATAD3A antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

References

Ota T., et al. Nat. Genet. 36:40-45(2004). Gregory S.G., et al. Nature 441:315-321(2006). Bienvenut W.V., et al. Submitted (JUL-2007) to UniProtKB. Daub H., et al. Mol. Cell 31:438-448(2008). Choudhary C., et al. Science 325:834-840(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 283436220
• NCBI GeneID: 55210
• NCBI Accession #: NP_060658.3; NP_001164007.1
• NCBI GenBank Nucleotide #: NP_060658.3
• UniProt Accession #: Q9NVI7; Q5T9A4
• Molecular Weight: 71369
• NCBI Official Full Name: ATPase family AAA domain-containing protein 3A isoform 1
• NCBI Official Synonym Full Names: ATPase family AAA domain containing 3A
• NCBI Official Symbol: ATAD3A
• NCBI Official Synonym Symbols: HAYOS
• NCBI Protein Information: ATPase family AAA domain-containing protein 3A
• UniProt Protein Name: ATPase family AAA domain-containing protein 3A
• Protein Family: ATPase family AAA domain-containing protein
• UniProt Gene Name: ATAD3A
• UniProt Entry Name: ATD3A_HUMAN

NCBI Description

This gene encodes a ubiquitously expressed mitochondrial membrane protein that contributes to mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. This gene is a member of the ATPase family AAA-domain containing 3 gene family which, in humans, includes two other paralogs. Naturally occurring mutations in this gene are associated with distinct neurological syndromes including Harel-Yoon syndrome. High-level expression of this gene is associated with poor survival in breast cancer patients. A homozygous knockout of the orthologous gene in mice results in embryonic lethality at day 7.5 due to growth retardation and defective development of the trophoblast lineage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Description

ATAD3A: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. Belongs to the AAA ATPase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: ATP binding

Biological Process: cell growth; negative regulation of apoptosis