Rabbit anti-Human CAMK1D Polyclonal Antibody | anti-CAMK1D antibody

CAMK1D Antibody

Cat. Num. AAA9412100

• Gene Names: CAMK1D; CKLiK; CaM-K1; CaMKID
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: CAMK1D; Polyclonal Antibody; CAMK1D Antibody; CKLiK; CaM-K1; CaMKID; anti-CAMK1D antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CAMK1D protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.1 mg/ml (varies by lot)
• Sequence Length: 357

• Applicable Applications for anti-CAMK1D antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human calcium/calmodulin-dependent protein kinase ID
• Target Name: CAMK1D
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/50.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/50.)

Related Product Information for anti-CAMK1D antibody

This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. The encoded protein may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Product Categories/Family for anti-CAMK1D antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 9966875
• NCBI GeneID: 57118
• NCBI Accession #: NP_065130.1
• NCBI GenBank Nucleotide #: NM_020397.3
• UniProt Accession #: Q8IU85; Q9HD31; B0YIY0
• Molecular Weight: 40,190 Da
• NCBI Official Full Name: calcium/calmodulin-dependent protein kinase type 1D isoform 1
• NCBI Official Synonym Full Names: calcium/calmodulin-dependent protein kinase ID
• NCBI Official Symbol: CAMK1D
• NCBI Official Synonym Symbols: CKLiK; CaM-K1; CaMKID
• NCBI Protein Information: calcium/calmodulin-dependent protein kinase type 1D
• UniProt Protein Name: Calcium/calmodulin-dependent protein kinase type 1D
• Protein Family: Calcium/calmodulin-dependent protein kinase
• UniProt Gene Name: CAMK1D
• UniProt Synonym Gene Names: CAMKID; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CKLiK
• UniProt Entry Name: KCC1D_HUMAN

NCBI Description

This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]

Uniprot Description

CAMK1D: a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, CAMK; Kinase, protein; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK1 family

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: cytoplasm; nucleus

Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: positive regulation of apoptosis; positive regulation of phagocytosis; regulation of dendrite development; activation of CREB transcription factor; inflammatory response; protein amino acid phosphorylation; negative regulation of apoptosis