Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human bladder cancer using MBS715702 at dilution 1:100)
Rabbit anti-Human Calmodulin Polyclonal Antibody | anti-CALM2 antibody
Rabbit anti- human Calmodulin polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human bladder cancer using MBS715702 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human bladder cancer using MBS715702 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Uniprot Description
Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 14q32.11
Cellular Component: centrosome; cytoplasm; cytosol; extracellular region; growth cone; nucleoplasm; nucleus; plasma membrane; sarcomere; spindle microtubule; spindle pole; vesicle
Molecular Function: adenylate cyclase binding; calcium ion binding; calcium-dependent protein binding; N-terminal myristoylation domain binding; nitric-oxide synthase binding; nitric-oxide synthase regulator activity; phosphoinositide 3-kinase binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activator activity; thioesterase binding; titin binding; type 3 metabotropic glutamate receptor binding
Biological Process: activation of MAPKK activity; adenylate cyclase activation; axon guidance; blood coagulation; carbohydrate metabolic process; detection of calcium ion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; glucose metabolic process; glycogen catabolic process; innate immune response; inositol phosphate metabolic process; insulin receptor signaling pathway; MAPKKK cascade; muscle contraction; nerve growth factor receptor signaling pathway; nitric oxide metabolic process; phospholipase C activation; phototransduction, visible light; platelet activation; platelet degranulation; positive regulation of cyclic nucleotide metabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid dephosphorylation; Ras protein signal transduction; regulation of cytokinesis; regulation of heart rate; regulation of nitric-oxide synthase activity; regulation of rhodopsin mediated signaling; response to amphetamine; response to calcium ion; response to corticosterone stimulus; rhodopsin mediated signaling; signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; substantia nigra development; synaptic transmission; vascular endothelial growth factor receptor signaling pathway
Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
Research Articles on CALM2
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Product Notes
The CALM2 calm1 (Catalog #AAA715702) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti- human Calmodulin polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Calmodulin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CALM2 calm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calmodulin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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