Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human skin stained with MBS618661 using peroxidase-conjugate and AEC. Note membrane staining of epithelial cells)
Rabbit Cadherin, pan Polyclonal Antibody | anti-cad antibody
Cadherin, pan
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 2-4ug/ml for 2 hours at RT.
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 1:100 for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human skin stained with MBS618661 using peroxidase-conjugate and AEC. Note membrane staining of epithelial cells)
Immunohistochemistry (IHC)
(Formalin-fixed, paraffin-embedded human skin stained with MBS618661 using peroxidase-conjugate and AEC. Note membrane staining of epithelial cells)
NCBI and Uniprot Product Information
Uniprot Description
Function: Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation. Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box. Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation. These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg. Caudal is involved in regulation of proliferation through transactivation of the E2F gene. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora. Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location: Nucleus Ref.1.
Tissue specificity: Maternally localized in an anteroposterior gradient in the syncytial blastoderm. Also expressed in the pole cells. Zygotically localized in the primordia of the terminal abdominal segment, the hindgut and in the posterior midgut rudiment. Expressed in the gut, the gonads and parts of the genital disks of third instar larvae (at protein level). Ref.1
Developmental stage: Expressed both maternally and zygotically. Ref.1 Ref.6
Sequence similarities: Belongs to the Caudal homeobox family.Contains 1 homeobox DNA-binding domain.
Sequence caution: The sequence AAA28409.1 differs from that shown. Reason: Frameshift at positions 44 and 418.
Research Articles on cad
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Product Notes
The cad cad (Catalog #AAA618661) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cadherin, pan reacts with Bovine, Canine, Chicken, Human, Monkey, Mouse, Rat, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's Cadherin, pan can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: 2-4ug/ml for 2 hours at RT. Immunohistochemistry (Formalin-fixed, paraffin-embedded): 1:100 for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min. Researchers should empirically determine the suitability of the cad cad for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cadherin, pan, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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