Western Blot (WB)
(Western Blot: Sample: Recombinant CDH2, Human)
Rabbit anti-Human Cadherin Polyclonal Antibody | anti-CDH2 antibody
Polyclonal Antibody to Cadherin, Neuronal (CDH2)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant CDH2, Human)
Western Blot (WB)
(Western Blot: Sample: Recombinant CDH2, Human)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Breast cancer Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Breast cancer Tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
Uniprot Description
CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: apical plasma membrane; basolateral plasma membrane; catenin complex; cell junction; cell surface; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; fascia adherens; focal adhesion; integral component of membrane; intercalated disc; intercellular junction; lamellipodium; plasma membrane; postsynaptic density; sarcolemma
Molecular Function: alpha-catenin binding; beta-catenin binding; calcium ion binding; gamma-catenin binding; identical protein binding; protein binding; protein kinase binding; protein phosphatase binding
Biological Process: blood vessel morphogenesis; brain morphogenesis; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell migration; cell-cell adhesion mediated by cadherin; cellular protein metabolic process; cerebral cortex development; glial cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homeostasis of number of cells; homophilic cell adhesion; negative regulation of canonical Wnt signaling pathway; positive regulation of MAPK cascade; positive regulation of muscle cell differentiation; positive regulation of synaptic vesicle clustering; post-translational protein modification; protein localization to plasma membrane; radial glial cell differentiation; regulation of oligodendrocyte progenitor proliferation; striated muscle cell differentiation
Research Articles on CDH2
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Product Notes
The CDH2 cdh2 (Catalog #AAA2027401) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cadherin, Neuronal (CDH2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cadherin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the CDH2 cdh2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cadherin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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