Rabbit anti-Human, Mouse CA8 Polyclonal Antibody | anti-CA8 antibody

CA8 Polyclonal Antibody

Cat. Num. AAA2566719

• Gene Names: CA8; CALS; CARP; CAMRQ3; CA-VIII
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: CA8; Polyclonal Antibody; CA8 Polyclonal Antibody; CA-RP; CA-VIII; CALS; CAMRQ3; CARP; anti-CA8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-CA8 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant fusion protein of human CA8 (NP_0040473)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Mouse cerebellum using CA8 Polyclonal Antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-CA8 antibody

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-CA8 antibody

Cancer; Polyclonal Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 22027500
• NCBI GeneID: 767
• NCBI Accession #: NP_004047.3
• NCBI GenBank Nucleotide #: NM_004056.4
• UniProt Accession #: P35219; Q32MY2; A8K0A5; B3KQZ7
• Molecular Weight: 32,973 Da
• NCBI Official Full Name: carbonic anhydrase-related protein
• NCBI Official Synonym Full Names: carbonic anhydrase VIII
• NCBI Official Symbol: CA8
• NCBI Official Synonym Symbols: CALS; CARP; CAMRQ3; CA-VIII
• NCBI Protein Information: carbonic anhydrase-related protein; CA-related protein; carbonate dehydratase; carbonic anhydrase-like sequence
• UniProt Protein Name: Carbonic anhydrase-related protein
• Protein Family: Carbonic anhydrase-related protein
• UniProt Gene Name: CA8
• UniProt Synonym Gene Names: CALS; CARP; CA-VIII
• UniProt Entry Name: CAH8_HUMAN

NCBI Description

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. [provided by RefSeq, Jul 2008]

Uniprot Description

CA8: Does not have a carbonic anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation. Belongs to the alpha-carbonic anhydrase family.

Protein type: Energy Metabolism - nitrogen; Lyase

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: cytoplasm

Molecular Function: carbonate dehydratase activity; zinc ion binding

Biological Process: phosphoinositide-mediated signaling; one-carbon compound metabolic process

Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 3