Western Blot (WB)
(Western blot analysis of Mouse lung tissue lysate using C7 Polyclonal Antibody at dilution of 1:800)
Rabbit anti-Human, Mouse C7 Polyclonal Antibody | anti-C7 antibody
C7 Polyclonal Antibody
ELISA: 1:5000-1:10000
Western Blot (WB)
(Western blot analysis of Mouse lung tissue lysate using C7 Polyclonal Antibody at dilution of 1:800)
Western Blot (WB)
(Western blot analysis of Mouse lung tissue lysate using C7 Polyclonal Antibody at dilution of 1:800)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Uniprot Description
C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: membrane attack complex; extracellular region
Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation
Disease: Complement Component 7 Deficiency
Research Articles on C7
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Product Notes
The C7 c7 (Catalog #AAA2560463) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The C7 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's C7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:2000 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the C7 c7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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