Rabbit C2TA Polyclonal Antibody | anti-C2TA antibody

C2TA antibody

Cat. Num. AAA839408

• Gene Names: Ciita; C2ta; Gm9475; Mhc2ta; EG669998
• Applications: Western Blot
• Synonyms: C2TA; Polyclonal Antibody; C2TA antibody; Polyclonal C2TA; Anti-C2TA; CTA-2; CTA 2; anti-C2TA antibody

• Host: Rabbit
• Clonality: Polyclonal
• Form/Format: Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 302

• Applicable Applications for anti-C2TA antibody: Western Blot (WB)
• Application Notes: WB: 0.125 ug/ml
• Biological Significance: C2ta is essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. C2ta may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter
• Cross-Reactivity: Mouse, Rat, Dog
• Immunogen: C2TA antibody was raised in rabbit using the C terminal of C2TA as the immunogen
• Preparation and Storage: Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-C2TA antibody

Affinity purified rabbit polyclonal C2TA antibody

Product Categories/Family for anti-C2TA antibody

DNA & RNA; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 76828169
• NCBI GeneID: 12265
• Molecular Weight: 116,233 Da
• NCBI Official Full Name: C2ta protein
• NCBI Official Synonym Full Names: class II transactivator
• NCBI Official Symbol: Ciita
• NCBI Official Synonym Symbols: C2ta; Gm9475; Mhc2ta; EG669998
• NCBI Protein Information: MHC class II transactivator
• UniProt Protein Name: MHC class II transactivator
• UniProt Gene Name: Ciita
• UniProt Synonym Gene Names: C2ta; Mhc2ta; CIITA
• UniProt Entry Name: C2TA_MOUSE

NCBI Description

This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Uniprot Description

CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production.

Protein type: DNA-binding; Transcription, coactivator/corepressor; EC 2.7.11.1

Cellular Component: PML body; cell surface; nucleus

Molecular Function: glucosaminyl-phosphotidylinositol O-acyltransferase activity; S-malonyltransferase activity; S-acetyltransferase activity; O-octanoyltransferase activity; O-sinapoyltransferase activity; palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; peptidyl-lysine N6-myristoyltransferase activity; azetidine-2-carboxylic acid acetyltransferase activity; Ras palmitoyltransferase activity; protein complex binding; palmitoyltransferase activity; C-palmitoyltransferase activity; ATP binding; octanoyltransferase activity; malonyltransferase activity; O-succinyltransferase activity; sterol O-acyltransferase activity; nucleotide binding; O-acyltransferase activity; O-acetyltransferase activity; transferase activity; benzoyl acetate-CoA thiolase activity; sinapoyltransferase activity; S-acyltransferase activity; N-succinyltransferase activity; L-2-aminoadipate N-acetyltransferase activity; keto acid formate lyase activity; GTP binding; 3-hydroxybutyryl-CoA thiolase activity; acyl-CoA N-acyltransferase activity; peptidyl-lysine N6-palmitoyltransferase activity; dihydrolipoamide branched chain acyltransferase activity; succinyltransferase activity; C-acyltransferase activity; dihydrolipoamide S-acyltransferase activity; protein C-terminus binding; protein-cysteine S-acyltransferase activity; N-acetyltransferase activity; serine O-acyltransferase activity; O-palmitoyltransferase activity; transcription activator binding; carnitine O-acyltransferase activity; 3-ketopimelyl-CoA thiolase activity; S-succinyltransferase activity; N-acyltransferase activity; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity; N-palmitoyltransferase activity; acylglycerol O-acyltransferase activity; protein-cysteine S-myristoyltransferase activity; myristoyltransferase activity; acetyltransferase activity; transferase activity, transferring acyl groups; kinase activity

Biological Process: response to antibiotic; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation