Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/25.)
Rabbit anti-Human C1QTNF3 Polyclonal Antibody | anti-C1QTNF3 antibody
C1QTNF3 Antibody
Gene Names
C1QTNF3; CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
C1QTNF3; Polyclonal Antibody; C1QTNF3 Antibody; CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26; anti-C1QTNF3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total C1QTNF3 protein.
Purity/Purification
Antigen Affinity Purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.8 mg/ml (varies by lot)
Sequence Length
246
Applicable Applications for anti-C1QTNF3 antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:25-1:100
Immunogen
Fusion protein of human C1QTNF3
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/25.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/25.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/25.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/25.)
Related Product Information for anti-C1QTNF3 antibody
C1qTNF3 (Complement C1q TNF-related protein 3/CTRP3; also CORS26 and cartonectin) is a 30-32 kDa, secreted member of the C1q and TNF-related protein (CTRP) superfamily of molecules. It is expressed by a wide variety of cells, including smooth muscle cells, fibroblasts, adipocytes, monocytes and proliferating chondrocytes. C1qTNF3 is an anti-inflammatory agent that apparently blocks LPS activation of mononuclear cells.It also has marked proliferative activity on diverse cell types such as vascular smooth muscle, chrondrocytes, and endothelium. Finally, C1qTNF3 is known to act on hepatocytes and suppress hepatocyte gluconeogenesis. Mature human C1qTNF3 is 224 amino acids (aa) in length (aa 23-246). It possesses an N-terminal collagen-like domain (aa 51-113) followed by a C-terminal globular region (aa 113-246). C1qTNF3 is monomeric when intracellular, but forms a 90 kDa homotrimer plus higher-order oligomer when secreted. There are at least two potential isoform variants.One is 40-42 kDa, glycosylated, and contains a 73 aa insertion after Glu28, while a second shows concurrent deletions of aa 46-69 and 82-105. The longer 40 kDa isoform is reported to form heterotrimers and oligomers with the standard 30 kDa isoform. This has the effect of protecting the standard isoform from proteolysis. Over aa 24-246, human C1qTNF3 shares 99% aa sequence identity with mouse C1qTNF3.
Product Categories/Family for anti-C1QTNF3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
35,183 Da
NCBI Official Full Name
complement C1q tumor necrosis factor-related protein 3 isoform a
NCBI Official Synonym Full Names
C1q and tumor necrosis factor related protein 3
NCBI Official Symbol
C1QTNF3
NCBI Official Synonym Symbols
CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26
NCBI Protein Information
complement C1q tumor necrosis factor-related protein 3
UniProt Protein Name
Complement C1q tumor necrosis factor-related protein 3
Protein Family
UniProt Gene Name
C1QTNF3
UniProt Synonym Gene Names
CTRP3; CORS26
UniProt Entry Name
C1QT3_HUMAN
Uniprot Description
C1QTNF3: 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: extracellular space; membrane
Biological Process: fat cell differentiation; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of NF-kappaB import into nucleus; positive regulation of cytokine secretion
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Product Notes
The C1QTNF3 c1qtnf3 (Catalog #AAA9416075) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The C1QTNF3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's C1QTNF3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the C1QTNF3 c1qtnf3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C1QTNF3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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