Rabbit C1QB Polyclonal Antibody | anti-C1QB antibody

C1QB (Complement Component 1, q Subcomponent, B Chain) (FITC)

Cat. Num. AAA6409075

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: C1QB; Polyclonal Antibody; C1QB (Complement Component 1; q Subcomponent; B Chain) (FITC); anti-C1QB antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes C1QB. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-C1QB antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human C1QB.
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of mouse liver, using C1QB antibody.)

Product Categories/Family for anti-C1QB antibody

Antibodies; Complement

NCBI and Uniprot Product Information

• NCBI GI #: 87298828
• NCBI GeneID: 713
• NCBI Accession #: NP_000482.3
• NCBI GenBank Nucleotide #: NM_000491.3
• UniProt Accession #: P02746; Q5T959; Q96H17
• Molecular Weight: 26,722 Da
• NCBI Official Full Name: complement C1q subcomponent subunit B
• NCBI Official Synonym Full Names: complement component 1, q subcomponent, B chain
• NCBI Official Symbol: C1QB
• NCBI Protein Information: complement C1q subcomponent subunit B; complement component C1q, B chain; complement subcomponent C1q chain B; complement component 1, q subcomponent, beta polypeptide
• UniProt Protein Name: Complement C1q subcomponent subunit B
• Protein Family: Complement C1q subcomponent
• UniProt Gene Name: C1QB
• UniProt Entry Name: C1QB_HUMAN

NCBI Description

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]

Uniprot Description

C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: innate immune response; inner ear development; complement activation, classical pathway; complement activation

Disease: C1q Deficiency