Immunohistochemistry (IHC)
(Sample Data: Immunohistochemical staining of formalin-fixed paraffin-embedded tonsil showing membrane staining with Anti-c-KIT dilution: 1:100.)
Rabbit anti-Human c-KIT Polyclonal Antibody | anti-c-KIT antibody
Anti-c-KIT
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Affinity chromatography
Synonyms
c-KIT; Polyclonal Antibody; Anti-c-KIT; anti-c-KIT antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit, IgG
Specificity
Recognizes the c-KIT protein
Purity/Purification
Affinity chromatography
Form/Format
PBS, pH7.4 with 0.02% Sodium Azide
Applicable Applications for anti-c-KIT antibody
ELISA (EIA), Immunohistochemistry (IHC)
Immunogen
Rabbit polyclonal c-KIT antibody was raised against a 16 amino acid peptide from near the C-terminal residues of human c-kit protein.
Preparation and Storage
Store at 4 degree C (add 0.1% NaN3) for several months, and at -20 degree C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
1 year at -20 degree C from date of shipment
1 year at -20 degree C from date of shipment
Immunohistochemistry (IHC)
(Sample Data: Immunohistochemical staining of formalin-fixed paraffin-embedded tonsil showing membrane staining with Anti-c-KIT dilution: 1:100.)
Immunohistochemistry (IHC)
(Sample Data: Immunohistochemical staining of formalin-fixed paraffin-embedded tonsil showing membrane staining with Anti-c-KIT dilution: 1:100.)
Related Product Information for anti-c-KIT antibody
c-KIT is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT together with its ligand regulates growth and activation of a variety of hematopoietic and non-hematopoietic cells. Mutations in c-KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed curbing neoplastic mast cell growth (2).
Product Categories/Family for anti-c-KIT antibody
References
1. Berger, S A.: Signaling pathways influencing SLF and c-kit-mediated survival and proliferation. Immunol Res. 2006;35(1-2):1-12.
2. Gotlib, J.: KIT mutations in mastocytosis and their potential as therapeutic targets. Immunol Allergy Clin North Am. 2006 Aug;26(3):575-92.
3. Beghini,A., Larizza,L., Cairoli,R.et,al. c-kit activating mutations and mast cell proliferation in human leukemia. Blood. 1998; 92 (2):701-702.
2. Gotlib, J.: KIT mutations in mastocytosis and their potential as therapeutic targets. Immunol Allergy Clin North Am. 2006 Aug;26(3):575-92.
3. Beghini,A., Larizza,L., Cairoli,R.et,al. c-kit activating mutations and mast cell proliferation in human leukemia. Blood. 1998; 92 (2):701-702.
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Product Notes
The c-KIT (Catalog #AAA516039) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-c-KIT reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's c-KIT can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the c-KIT for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "c-KIT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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