Rabbit anti-Human, Mouse BRS3 Polyclonal Antibody | anti-BRS3 antibody

BRS3, ID (BRS3, Bombesin receptor subtype-3)

Cat. Num. AAA6009338

• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: BRS3; Polyclonal Antibody; ID (BRS3; Bombesin receptor subtype-3); Anti -BRS3; anti-BRS3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-BRS3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: BRS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246~276 amino acids from the Central region of human BRS3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of BRS3 Antibody (Center) in mouse stomach tissue lysates (35ug/lane). BRS3 (arrow) was detected using the purified Pab.)

Related Product Information for anti-BRS3 antibody

Mammalian bombesin-like peptides (see MIM 137260) are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor (MIM 305670), neuromedin B receptor (MIM 162341), and bombesin-like receptor-3 (BRS3) (Ohki-Hamazaki et al., 1997).

Product Categories/Family for anti-BRS3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4502455
• NCBI GeneID: 680
• NCBI Accession #: NP_001718.1
• NCBI GenBank Nucleotide #: NM_001727.1
• UniProt Accession #: P32247
• Molecular Weight: 44,411 Da
• NCBI Official Full Name: bombesin receptor subtype-3
• NCBI Official Synonym Full Names: bombesin-like receptor 3
• NCBI Official Symbol: BRS3
• NCBI Protein Information: bombesin receptor subtype-3; BRS-3; G-protein coupled receptor; bombesin receptor subtype 3
• UniProt Protein Name: Bombesin receptor subtype-3
• Protein Family: Bombesin receptor
• UniProt Gene Name: BRS3
• UniProt Synonym Gene Names: BRS-3
• UniProt Entry Name: BRS3_HUMAN

NCBI Description

The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

Uniprot Description

BRS3: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: neuron projection; cell soma; integral to membrane; plasma membrane

Molecular Function: bombesin receptor activity

Biological Process: regulation of blood pressure; bombesin receptor signaling pathway; glucose metabolic process; adult feeding behavior