Rabbit LANCL2 Polyclonal Antibody | anti-LANCL2 antibody

LANCL2 Antibody

Cat. Num. AAA154355

• Gene Names: LANCL2; TASP; GPR69B
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column.
• Synonyms: LANCL2; Polyclonal Antibody; LANCL2 Antibody; LanC lantibiotic synthetase component C-like 2; GPR69B; LanC-like protein 2; TASP; Testis-specific adriamycin sensitivity protein; anti-LANCL2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: LANCL2 antibody is human, mouse and rat reactive.
• Purity/Purification: Affinity chromatography purified via peptide column.
• Form/Format: Liquid; Supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 450

• Applicable Applications for anti-LANCL2 antibody: ELISA, Western Blot (WB), Immunohistochemistry - Paraffin (IHC-P)
• Application Notes: LANCL2 antibody can be used for the detection of LANCL2 by Western blot at 1 - 2 ug/mL. ; Antibody can also be used for immunohistochemistry starting at 5 ug/mL.; ; Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.; ; Optimal dilutions for each application to be determined by the researcher.
• Immunogen: LANCL2 antibody was raised against a 16 amino acid peptide from near the amino terminus of human LANCL2.; The immunogen is located within amino acids 30-80 of LANCL2.
• Positive Control 1: MBS151732 Human Brain Tissue Lysate
• Conjugate: Unconjugated
• Preparation and Storage: Short Term: 4°C; Long Term: -20°C

Western Blot (WB)

(Western blot analysis of LANCL2 in human brain tissue lysate with LANCL2 antibody at 1 μg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of LANCL2 in mouse brain tissue with LANCL2 antibody at 5 μg/mL.)

Related Product Information for anti-LANCL2 antibody

LANCL2 (LanC-like protein 2), also known as TASP (testis-specific adriamycin sensitivity protein) or GPR69B, is a 450 amino acid member of the LanC-like protein family (1). It is expressed highly in brain and testis and localized to the nucleus, cytoplasm and cell membrane (2,3). LANCL2 is necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes (3,4).

Product Categories/Family for anti-LANCL2 antibody

Signal Transduction

References

Mayer H, Pongratz M, and Prohaska R. Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. DNA Seq. 2001; 12:161-6. Sturla L, Fresia C, Guida L, et al. Binding of abscisic acid to human LANCL2. Biochem. Biophys. Res. Commun. 2011; 415:390-5. Landlinger C, Salzer U, and Prohaska R. Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. Biochim. Biophys. Acta. 2006; 1758:1759-67. Zeng M, van der Donk WA, Chen J. Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. Mol. Biol. Cell 2014; 25:3954-61.

NCBI and Uniprot Product Information

• NCBI GI #: 8923911
• NCBI GeneID: 55915
• NCBI Accession #: NP_061167
• NCBI GenBank Nucleotide #: NM_018697.3
• UniProt Accession #: Q9NS86; Q6NSL4; Q8TCQ3; Q9BSR1; B2R8D4
• Molecular Weight: Predicted: 50 kDa; Observed: 48 kDa
• NCBI Official Full Name: lanC-like protein 2
• NCBI Official Synonym Full Names: LanC like 2
• NCBI Official Symbol: LANCL2
• NCBI Official Synonym Symbols: TASP; GPR69B
• NCBI Protein Information: lanC-like protein 2
• UniProt Protein Name: LanC-like protein 2
• Protein Family: LanC-like protein
• UniProt Gene Name: LANCL2
• UniProt Synonym Gene Names: GPR69B; TASP
• UniProt Entry Name: LANC2_HUMAN

Uniprot Description

LANCL2: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Belongs to the LanC-like protein family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 7q31.1-q31.33

Cellular Component: cortical actin cytoskeleton; cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function: ATP binding; catalytic activity; GTP binding; phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding

Biological Process: metabolic process; negative regulation of transcription, DNA-dependent; positive regulation of abscisic acid mediated signaling