Rabbit anti-Human Bone Morphogenetic Protein 2 Inducible Kinase Polyclonal Antibody | anti-BMP2K antibody

Bone Morphogenetic Protein 2 Inducible Kinase (BMP-2 Inducible Protein Kinase, BMP2 Inducible Kinase, BMP2 Inducible Protein Kinase, BIKE, BMP2K, DKFZp434K0614, DKFZp434P0116, HRIHFB2017)

Cat. Num. AAA620831

• Gene Names: BMP2K; BIKE; HRIHFB2017; DKFZp434K0614; DKFZp434P0116
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Bone Morphogenetic Protein 2 Inducible Kinase; Polyclonal Antibody; Bone Morphogenetic Protein 2 Inducible Kinase (BMP-2 Inducible Protein Kinase; BMP2 Inducible Kinase; BMP2 Inducible Protein Kinase; BIKE; BMP2K; DKFZp434K0614; DKFZp434P0116; HRIHFB2017); Anti -Bone Morphogenetic Protein 2 Inducible Kinase (BMP-2 Inducible Protein Kinase; anti-BMP2K antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BMP2K.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid.

• Applicable Applications for anti-BMP2K antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry: Paraffin
• Immunogen: KLH conjugated Amino acids 274 to 291 of human BMP2K.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(BMP-2K (BIKE) staining of paraffin embedded human skin)

Related Product Information for anti-BMP2K antibody

There are at least 20 structurally and functionally related BMPs, which are members of the TGF-beta superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. They are also involved in embryogenesis and morphogenesis of various tissues and organs. BMPs regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similar to other TGF-beta family proteins, BMPs are highly conserved across animal species. BMP2K has a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-BMP2K antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 38787904
• NCBI GeneID: 55589
• NCBI Accession #: NP_060063.2
• NCBI GenBank Nucleotide #: NM_017593.3
• UniProt Accession #: Q4W5H2; Q9NSY1
• Molecular Weight: 73,838 Da
• NCBI Official Full Name: BMP-2-inducible protein kinase isoform b
• NCBI Official Synonym Full Names: BMP2 inducible kinase
• NCBI Official Symbol: BMP2K
• NCBI Official Synonym Symbols: BIKE; HRIHFB2017; DKFZp434K0614; DKFZp434P0116
• NCBI Protein Information: BMP-2-inducible protein kinase; OTTHUMP00000219234
• UniProt Protein Name: Putative uncharacterized protein BMP2K
• Protein Family: BMP-2-inducible protein kinase
• UniProt Gene Name: BMP2K
• UniProt Entry Name: Q4W5H2_HUMAN

NCBI Description

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

BIKE: May be involved in osteoblast differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; NAK family

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: nucleoplasm

Molecular Function: protein serine/threonine kinase activity; phosphatase regulator activity; ATP binding

Biological Process: regulation of catalytic activity; protein amino acid phosphorylation; regulation of bone mineralization