Western Blot (WB)
(Western blot analysis of BMPR1B expression in mouse brain (A) whole cell lysates.)
Rabbit anti-Human, Mouse BMPR1B Polyclonal Antibody | anti-BMPR1B antibody
Anti-BMPR1B Antibody
Western Blot (WB)
(Western blot analysis of BMPR1B expression in mouse brain (A) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of BMPR1B expression in mouse brain (A) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of BMPR1B staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of BMPR1B staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunofluorescence (IF)
(Immunofluorescent analysis of BMPR1B staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.)
Immunofluorescence (IF)
(Immunofluorescent analysis of BMPR1B staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Description
BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.
Protein type: Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 4q22-q24
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; chondrocyte development; eye development; limb morphogenesis; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; skeletal development
Disease: Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies
Research Articles on BMPR1B
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Product Notes
The BMPR1B bmpr1b (Catalog #AAA8247274) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-BMPR1B Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's BMPR1B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC). WB: 1/500 - 1/2000; IHC: 1/50 - 1/200; IF/IC: 1/50 - 1/200. Researchers should empirically determine the suitability of the BMPR1B bmpr1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BMPR1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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