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Rabbit anti-Human BMP2 BMP2 Polyclonal Antibody | anti-BMP2 antibody

BMP2 antibody

Reactivity
Human BMP2
Applications
ELISA, Western Blot
Synonyms
BMP2; Polyclonal Antibody; BMP2 antibody; Polyclonal BMP2; Anti-BMP2; BMP-2; BMP 2; Bone Morphogenetic; BMP-2A; 2; anti-BMP2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human BMP2
Clonality
Polyclonal
Specificity
Human BMP2
Form/Format
Lyophilized from PBS, pH 7.2. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/ml.
Sequence Length
393
Applicable Applications for anti-BMP2 antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes
ELISA: 0.5-2 ug/ml
Inhibition: 1.3-1.9 ug/ml
WB: 0.1-0.2 ug/ml
Biological Significance
BMPs (Bone Morphogenetic Proteins) belong to the TGF beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond.
Cross-Reactivity
Mouse, Rat
Immunogen
BMP2 antibody was raised in rabbit using highly pure human recombinant human BMP-2 as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-BMP2 antibody
Affinity purified Rabbit polyclonal BMP2 antibody
Product Categories/Family for anti-BMP2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
26 kDa (predicted detection band MW)
NCBI Official Full Name
bone morphogenetic protein 2
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
Bmp2
NCBI Protein Information
bone morphogenetic protein 2
UniProt Protein Name
Bone morphogenetic protein 2
UniProt Gene Name
Bmp2
UniProt Synonym Gene Names
Bmp-2; BMP-2; BMP-2A
UniProt Entry Name
BMP2_RAT

NCBI Description

involved in cellular signaling during limb development; induces bone formation [RGD, Feb 2006]

Uniprot Description

BMP2: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; protein complex; cell surface; cytoplasm; extracellular region

Molecular Function: protein domain specific binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; phosphatase activator activity; cytokine activity; SMAD binding; transforming growth factor beta receptor binding; retinol dehydrogenase activity; receptor binding

Biological Process: activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; heart development; adrenocorticotropin hormone secreting cell differentiation; telencephalon regionalization; protein amino acid phosphorylation; cardiac muscle cell differentiation; BMP signaling pathway; regulation of apoptosis; ovulation cycle; chondrocyte differentiation; inner ear development; regulation of odontogenesis of dentine-containing teeth; positive regulation of astrocyte differentiation; pericardium development; positive regulation of neurogenesis; cell fate commitment; organ morphogenesis; mesenchymal cell differentiation; response to mechanical stimulus; regulation of MAPKKK cascade; positive regulation of osteoblast proliferation; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; positive regulation of cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of calcium-independent cell-cell adhesion; positive regulation of odontogenesis; proteoglycan metabolic process; embryonic heart tube anterior/posterior pattern formation; negative regulation of insulin-like growth factor receptor signaling pathway; thyroid stimulating hormone secreting cell differentiation; negative regulation of transcription from RNA polymerase II promoter; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; negative regulation of aldosterone biosynthetic process; cardiac muscle morphogensis; inflammatory response; positive regulation of Wnt receptor signaling pathway; cardiac cell differentiation; ossification; Notch signaling pathway; response to retinoic acid; protein destabilization; in utero embryonic development; positive regulation of bone mineralization; positive regulation of ossification; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of osteoblast differentiation; telencephalon development; ureteric bud branching; cartilage development; response to hypoxia; epithelial to mesenchymal transition; positive regulation of protein amino acid phosphorylation; positive regulation of neuron differentiation; positive regulation of cell migration; growth

Research Articles on BMP2

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Product Notes

The BMP2 bmp2 (Catalog #AAA534101) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BMP2 antibody reacts with Human BMP2 and may cross-react with other species as described in the data sheet. AAA Biotech's BMP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB). ELISA: 0.5-2 ug/ml Inhibition: 1.3-1.9 ug/ml WB: 0.1-0.2 ug/ml. Researchers should empirically determine the suitability of the BMP2 bmp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BMP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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