Western Blot (WB)
(Western Blot: Sample: Lane1: Human Leukocytes Cells; Lane2: Human Liver Tissue; Lane3: Human Urine.)
Rabbit anti-Human Beta-2-Microglobulin (b2M) Polyclonal Antibody | anti-b2M antibody
Polyclonal Antibody to Beta-2-Microglobulin (b2M)
MGHHHHHHSGS-QRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Human Leukocytes Cells; Lane2: Human Liver Tissue; Lane3: Human Urine.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Human Leukocytes Cells; Lane2: Human Liver Tissue; Lane3: Human Urine.)
Western Blot (WB)
(Western Blot: Sample: Recombinant b2M, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant b2M, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Rectum Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Rectum Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Uniprot Description
B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: cytosol; early endosome membrane; endoplasmic reticulum lumen; external side of plasma membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; Golgi membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane
Molecular Function: identical protein binding; protein binding
Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; ferric iron import; innate immune response; iron ion homeostasis; neutrophil degranulation; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protein refolding; regulation of defense response to virus by virus; regulation of erythrocyte differentiation; regulation of immune response; response to cadmium ion; response to drug; response to molecule of bacterial origin; retinal homeostasis; T cell differentiation in thymus
Disease: Amyloidosis, Familial Visceral; Hypoproteinemia, Hypercatabolic
Research Articles on b2M
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Product Notes
The b2M b2m (Catalog #AAA2001827) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Beta-2-Microglobulin (b2M) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Beta-2-Microglobulin (b2M) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the b2M b2m for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with a His-tag and its sequence is listed below. MGHHHHHHSG S-QRTPKIQV Y SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM. It is sometimes possible for the material contained within the vial of "Beta-2-Microglobulin (b2M), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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