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Immunohistochemistry (IHC) (Anti-BDKRB2/Bradykinin B2 Receptor antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit BDKRB2/Bradykinin B2 Receptor Polyclonal Antibody | anti-BDKRB2 antibody

Rabbit Polyclonal to Human BDKRB2/Bradykinin B2 Receptor

Gene Names
BDKRB2; B2R; BK2; BK-2; BKR2; BRB2
Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, Immunocytochemistry
Purity
Immunoaffinity Purified
Synonyms
BDKRB2/Bradykinin B2 Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human BDKRB2/Bradykinin B2 Receptor; Anti-BDKRB2/Bradykinin B2 Receptor Antibody (C-Terminus) IHC-plus; BDKRB2; BK-2 receptor; Bradykinin type-2 receptor; B2R; Bradykinin B2 receptor; BRB2; BK-2R; BK-2Rs; BK2; B2 bradykinin receptor; B2bkr; BK-2; BKR2; Bradykinin receptor B2; Human BDKRB2/Bradykinin B2 Receptor; anti-BDKRB2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human BDKRB2 / BK-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BAHD1 (44%).
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
391
Applicable Applications for anti-BDKRB2 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)
Application Notes
ICC, IHC-P (5 - 10 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from C-terminus of human BDKRB2 / BK-2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset (94%); Mouse, Pig (83%).
Immunogen Type
Synthetic peptide
Immunogen
BDKRB2/Bradykinin B2 Receptor antibody was raised against synthetic 18 amino acid peptide from C-terminus of human BDKRB2 / BK-2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset (94%); Mouse, Pig (83%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-BDKRB2/Bradykinin B2 Receptor antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-BDKRB2/Bradykinin B2 Receptor antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC) (Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Anti-BDKRB2/Bradykinin B2 Receptor antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-BDKRB2/Bradykinin B2 Receptor antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Transfection

(Anti-BDKRB2 / BK-2 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with BDKRB2 / BK-2.)

Transfection (Anti-BDKRB2 / BK-2 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with BDKRB2 / BK-2.)

Transfection Control

(Anti-BDKRB2 / BK-2 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.)

Transfection Control (Anti-BDKRB2 / BK-2 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.)
Related Product Information for anti-BDKRB2 antibody
Bradykinin Receptor B2 mediates smooth muscle contraction, induces relaxation of arteries, and stimulates diuresis. In addition, bradykinin B2 receptor has been implicated in inflammation and response to pain. This receptor is encoded by a single-copy gene. Two variants are produced by alternate start codons.
Product Categories/Family for anti-BDKRB2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
624
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
41,441 Da
NCBI Official Full Name
B2 bradykinin receptor
NCBI Official Synonym Full Names
bradykinin receptor B2
NCBI Official Symbol
BDKRB2
NCBI Official Synonym Symbols
B2R; BK2; BK-2; BKR2; BRB2
NCBI Protein Information
B2 bradykinin receptor; BK-2 receptor
UniProt Protein Name
B2 bradykinin receptor
Protein Family
UniProt Gene Name
BDKRB2
UniProt Synonym Gene Names
BKR2; B2R; BK-2 receptor
UniProt Entry Name
BKRB2_HUMAN

NCBI Description

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

Uniprot Description

BKR2: a receptor for bradykinin. Bradykinin elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q32.1-q32.2

Cellular Component: integral to plasma membrane; plasma membrane; endosome

Molecular Function: bradykinin receptor activity; protein binding; protease binding; protein heterodimerization activity; type 1 angiotensin receptor binding; phosphoinositide phospholipase C activity

Biological Process: vasoconstriction; metabolic process; blood circulation; negative regulation of peptidyl-serine phosphorylation; arachidonic acid secretion; vasodilation; response to salt stress; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; smooth muscle contraction; regulation of vasoconstriction; regulation of vascular permeability; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on BDKRB2

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Product Notes

The BDKRB2 bdkrb2 (Catalog #AAA242927) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human BDKRB2/Bradykinin B2 Receptor reacts with Gibbon, Gorilla, Human Predicted Reactivity: Monkey (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's BDKRB2/Bradykinin B2 Receptor can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC). ICC, IHC-P (5 - 10 ug/ml). Researchers should empirically determine the suitability of the BDKRB2 bdkrb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BDKRB2/Bradykinin B2 Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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