Structure
eIF4A3 inhibitor 53a Biochemical
eIF4A3 inhibitor 53a
Purity
>98% (HPLC)
Synonyms
eIF4A3 inhibitor 53a; eIF4A3 inhibitor 53a biochemical
Purity/Purification
>98% (HPLC)
Target
eIF
Receptor
eIF
Chemical Name
3-(4-(((3S)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)-piperazin-1-yl)carbonyl)-5-methyl-1H-pyrazol-1-yl)-benzonitrile
SMILES
ClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2
Molecular Formula
C29H23BrClN5O2
CAS Number
2095486-67-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for eIF4A3 inhibitor 53a biochemical
eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26uM, SPR Kd of 43nM; displays no activity against eIF4A1, eIF4A2, DHX29 and BRR2 ATPase (IC50>100uM); binds to a non-ATP binding site of eIF4A3, exhibits cellular nonsense-mediated RNA decay (NMD) inhibitory activity and represents a novel molecular probe for further study of eIF4A3, the exon junction complex (EJC) andnMD.
Product Categories/Family for eIF4A3 inhibitor 53a biochemical
References
1. Ito M, et al. J Med Chem. 2017 Apr 27; 60 (8):3335-3351.
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Product Notes
The eIF4A3 inhibitor 53a (Catalog #AAA3603295) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "eIF4A3 inhibitor 53a, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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