Rabbit anti-Mouse, Rat BCLAF1 Polyclonal Antibody | anti-BCLAF1 antibody

BCLAF1 Rabbit pAb

Cat. Num. AAA8550364

• Gene Names: BCLAF1; BTF; bK211L9.1
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: BCLAF1; Polyclonal Antibody; BCLAF1 Rabbit pAb; BTF; bK211L9.1; anti-BCLAF1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 869

• Applicable Applications for anti-BCLAF1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human BCLAF1 (NP_001070909.1).
• Cellular Localization: Cytoplasm, Nucleus
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-BCLAF1 antibody

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3' end of the CCND1 gene and its mRNA.

NCBI and Uniprot Product Information

• NCBI GI #: 117938251
• NCBI GeneID: 9774
• NCBI Accession #: NP_001070908.1
• NCBI GenBank Nucleotide #: NP_001070908.1
• UniProt Accession #: Q9NYF8
• Molecular Weight: 145kDa
• NCBI Official Full Name: bcl-2-associated transcription factor 1 isoform 2
• NCBI Official Synonym Full Names: BCL2 associated transcription factor 1
• NCBI Official Symbol: BCLAF1
• NCBI Official Synonym Symbols: BTF; bK211L9.1
• NCBI Protein Information: bcl-2-associated transcription factor 1
• UniProt Protein Name: Bcl-2-associated transcription factor 1
• Protein Family: Bcl-2-associated transcription factor
• UniProt Gene Name: BCLAF1
• UniProt Synonym Gene Names: BTF; KIAA0164; Btf
• UniProt Entry Name: BCLF1_HUMAN

NCBI Description

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BCLAF1: a ubiquitous death-promoting transcriptional repressor. Interacts with Bcl-2 related proteins, lamin A, emerin, the adenovirus E1B 19 kDa protein and DNA. An emerin mutant S54F, which binds normally to barrier-to-autointegration factor (BAF), lamin A and GCL, selectively disrupts its binding to BCLAF1. BCLAF1 is found in dot-like structures throughout the nuclear interior in HeLa cells. Proapoptotic stimuli induce its redistribution to a distinct zone near the nuclear envelope. Four alternatively spliced human isoforms have been described.

Protein type: RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: regulation of transcription in response to stress; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; negative regulation of transcription, DNA-dependent