Rabbit anti-Human, Mouse BCLAF1 Polyclonal Antibody | anti-BCLAF1 antibody

BCLAF1 Antibody

Cat. Num. AAA9415362

• Gene Names: BCLAF1; BTF; bK211L9.1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: BCLAF1; Polyclonal Antibody; BCLAF1 Antibody; BTF; bK211L9.1; anti-BCLAF1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total BCLAF1 protein.
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.7 mg/ml (varies by lot)
• Sequence Length: 869

• Applicable Applications for anti-BCLAF1 antibody: Immunohistochemistry (IHC)
• Immunogen: Synthetic peptide of human BCLAF1
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/25,)

Related Product Information for anti-BCLAF1 antibody

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoformshave been found for this gene.

Product Categories/Family for anti-BCLAF1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 117938251
• NCBI GeneID: 9774
• NCBI Accession #: NP_001070908.1
• NCBI GenBank Nucleotide #: NM_001077440.1
• UniProt Accession #: Q9NYF8; Q14673; Q86WU6; Q86WY0; A2RU75; B7ZM58; E1P586
• Molecular Weight: 85,937 Da
• NCBI Official Full Name: bcl-2-associated transcription factor 1 isoform 2
• NCBI Official Synonym Full Names: BCL2 associated transcription factor 1
• NCBI Official Symbol: BCLAF1
• NCBI Official Synonym Symbols: BTF; bK211L9.1
• NCBI Protein Information: bcl-2-associated transcription factor 1
• UniProt Protein Name: Bcl-2-associated transcription factor 1
• Protein Family: Bcl-2-associated transcription factor
• UniProt Gene Name: BCLAF1
• UniProt Synonym Gene Names: BTF; KIAA0164; Btf
• UniProt Entry Name: BCLF1_HUMAN

Uniprot Description

BCLAF1: a ubiquitous death-promoting transcriptional repressor. Interacts with Bcl-2 related proteins, lamin A, emerin, the adenovirus E1B 19 kDa protein and DNA. An emerin mutant S54F, which binds normally to barrier-to-autointegration factor (BAF), lamin A and GCL, selectively disrupts its binding to BCLAF1. BCLAF1 is found in dot-like structures throughout the nuclear interior in HeLa cells. Proapoptotic stimuli induce its redistribution to a distinct zone near the nuclear envelope. Four alternatively spliced human isoforms have been described.

Protein type: RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: nuclear speck; nucleolus; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding

Biological Process: apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of transcription in response to stress