Western Blot (WB)
(Western blot analysis of Bcl9L in HeLa cell lysate with Bcl9L antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Rabbit Bcl9L Polyclonal Antibody | anti-Bcl9L antibody
Bcl9L Antibody
Gene Names
BCL9L; BCL9-2; DLNB11
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
Bcl9L; Polyclonal Antibody; Bcl9L Antibody; B-cell CLL; lymphoma 9-like protein; Bcl9-2; B9L; DLNB11; anti-Bcl9L antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
Bcl9L antibody is predicted to not cross-react with other Bcl family members. At least four isoforms of Bcl9L are known to exist; this antibody will detect all four.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
1499
Applicable Applications for anti-Bcl9L antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 20 amino acid peptide near the amino terminus of human Bcl9L.
Target Name
Bcl9L
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of Bcl9L in HeLa cell lysate with Bcl9L antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of Bcl9L in HeLa cell lysate with Bcl9L antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Related Product Information for anti-Bcl9L antibody
Bcl9L, a homolog of Bcl9, was initially identified through a bioinformatics screening. It is expressed in fetal brain, adult lung, eye and prostate, in addition to several types of tumors including pancreatic and prostate cancers. Bcl9L has been shown to interact with beta-catenin, a target of the Wnt signaling pathway, and is required for enhanced beta-catenin-T-cell factor (TCF)-mediated transcription in colorectal tumor cells, possibly by translocating beta-catenin to the nucleus. Other studies have indicated that Bcl9L expression correlates with high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers, suggesting that activity may occur in other types of cancer. Bcl9L has also been shown to be critical for Wnt-mediate regulation of stem cell traits in colon epithelium and adenocarcinomas which are associated with tumor invasion, metastasis, and resistance to therapy.
Product Categories/Family for anti-Bcl9L antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
152,547 Da
NCBI Official Full Name
B-cell CLL/lymphoma 9-like protein
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 9-like
NCBI Official Symbol
BCL9L
NCBI Official Synonym Symbols
BCL9-2; DLNB11
NCBI Protein Information
B-cell CLL/lymphoma 9-like protein
UniProt Protein Name
B-cell CLL/lymphoma 9-like protein
Protein Family
UniProt Gene Name
BCL9L
UniProt Synonym Gene Names
DLNB11; B-cell lymphoma 9-like protein; BCL9-like protein
UniProt Entry Name
BCL9L_HUMAN
Uniprot Description
Bcl-9L: a novel beta-catenin-interacting protein that translocates beta-catenin to the nucleus, enhancing beta-catenin mediated transcription. Can play an important role in colorectal carcinogenesis. Nuclear expression of Bcl-9L is closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: transcription coactivator activity; beta-catenin binding
Biological Process: transcription, DNA-dependent; somatic stem cell maintenance; regulation of cell morphogenesis; positive regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on Bcl9L
Similar Products
Product Notes
The Bcl9L bcl9l (Catalog #AAA9407373) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bcl9L Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Bcl9L can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the Bcl9L bcl9l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bcl9L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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