Western Blot (WB)
(FADD Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the FADD antibody detected the FADD protein (arrow).)
Rabbit anti-Human FADD Polyclonal Antibody | anti-FADD antibody
FADD Antibody (Center)
Western Blot (WB)
(FADD Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the FADD antibody detected the FADD protein (arrow).)
Western Blot (WB)
(FADD Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the FADD antibody detected the FADD protein (arrow).)
that interacts with various cell surface receptors and mediates
cell apoptotic signals. Through its C-terminal death domain, this
protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis
factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it
participates in the death signaling initiated by these receptors.
Interaction of this protein with the receptors unmasks the
N-terminal effector domain of this protein, which allows it to
recruit caspase-8, and thereby activate the cysteine protease
cascade. Knockout studies in mice also suggest the importance of
this protein in early T cell development.
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Papoff, G., et al. Biochim. Biophys. Acta 1803(8):898-911(2010)
Li, P., et al. J. Biol. Chem. 285(29):22713-22722(2010)
Ko, C.L., et al. Chang Gung Med J 33(2):145-151(2010)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Uniprot Description
FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Protein type: Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: neuron projection; CD95 death-inducing signaling complex; cytosol; lipid raft
Molecular Function: identical protein binding; protein binding; protease binding; death receptor binding; protein complex binding; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding
Biological Process: viral reproduction; apoptosis; positive regulation of proteolysis; positive regulation of apoptosis; positive regulation of T cell mediated cytotoxicity; protein heterooligomerization; T cell differentiation in the thymus; toll-like receptor 3 signaling pathway; positive regulation of activated T cell proliferation; positive regulation of interleukin-8 production; T cell homeostasis; positive regulation of macrophage differentiation; toll-like receptor 4 signaling pathway; defense response to virus; positive regulation of adaptive immune response; caspase activation; spleen development; positive regulation of I-kappaB kinase/NF-kappaB cascade; thymus development; MyD88-independent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor production; lymph node development; positive regulation of interferon-gamma production; induction of apoptosis via death domain receptors; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter
Disease: Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations
Research Articles on FADD
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Product Notes
The FADD fadd (Catalog #AAA9214547) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 106-135. The FADD Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FADD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the FADD fadd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FADD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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