Rabbit Bcl-3 Polyclonal Antibody | anti-Bcl-3 antibody

Bcl-3 Antibody

Cat. Num. AAA840236

• Gene Names: BCL3; BCL4; D19S37
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: Bcl-3; Polyclonal Antibody; Bcl-3 Antibody; BCL3; D19S37; BCL4; anti-Bcl-3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.2 mg/ml) Protein G affinity purified rabbit anti-Bcl-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.2 mg/ml (varies by lot)
• Sequence Length: 454

• Applicable Applications for anti-Bcl-3 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Application Notes: Western blot analysis (2-4 ug/ml). Per researchers feedback, the antibody also works well in Immunoprecipation (10-20 ug/ml), and Immunohistochemistry (20-40 ug/ml). However, the optimal conditions should be determined individually. Detects 55-60 kDa Bcl-3 of human, mouse, and rat origins. Other species have not been tested.
• Immunogen: Synthetic peptide surrounding amino acid 424 of human Bcl-3
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-Bcl-3 antibody

Background: Bcl-3, a proto-oncogene, is believed to be involved in certain human B cell leukemias. It encodes a protein that functions as an IkB-like molecule for native NFkB, but is specific for the p50 subunit of NFkB.

NCBI and Uniprot Product Information

• NCBI GI #: 164664508
• NCBI GeneID: 602
• NCBI Accession #: NP_005169.2
• NCBI GenBank Nucleotide #: NM_005178.4
• UniProt Accession #: P20749
• Molecular Weight: 47,584 Da
• NCBI Official Full Name: B-cell lymphoma 3 protein
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 3
• NCBI Official Symbol: BCL3
• NCBI Official Synonym Symbols: BCL4; D19S37
• NCBI Protein Information: B-cell lymphoma 3 protein
• UniProt Protein Name: B-cell lymphoma 3 protein
• UniProt Gene Name: BCL3
• UniProt Synonym Gene Names: BCL4; D19S37; BCL-3
• UniProt Entry Name: BCL3_HUMAN

NCBI Description

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

Uniprot Description

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation ().