Rabbit anti-Human BAIAP2L1 Polyclonal Antibody | anti-BAIAP2L1 antibody

BAIAP2L1 (Brain-specific Angiogenesis Inhibitor 1-associated Protein 2-like Protein 1, BAI1-associated Protein 2-like Protein 1, Insulin Receptor Tyrosine Kinase Substrate, IRTKS) (FITC)

Cat. Num. AAA6370972

• Gene Names: BAIAP2L1; IRTKS
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: BAIAP2L1; Polyclonal Antibody; BAIAP2L1 (Brain-specific Angiogenesis Inhibitor 1-associated Protein 2-like Protein 1; BAI1-associated Protein 2-like Protein 1; Insulin Receptor Tyrosine Kinase Substrate; IRTKS) (FITC); anti-BAIAP2L1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BAIAP2L1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-BAIAP2L1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human BAIAP2L1, aa1-511 (NP_061330.2).
• Immunogen Sequence: MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGTAKPPFLSGENPFATVKLRPTVTNDRSAPIIR
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of BAIAP2L1 expression in transfected 293T cell line by BAIAP2L1 polyclonal antibody. Lane 1: BAIAP2L1 transfected lysate (56.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-BAIAP2L1 antibody

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Product Categories/Family for anti-BAIAP2L1 antibody

Antibodies; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 32171238
• NCBI GeneID: 55971
• NCBI Accession #: NP_061330.2
• NCBI GenBank Nucleotide #: NM_018842
• UniProt Accession #: Q9UHR4; Q75L21; Q75L22; Q96CV4; Q9H5F5; Q9Y2M8; A4D268
• Molecular Weight: 56,883 Da
• NCBI Official Full Name: brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
• NCBI Official Synonym Full Names: BAI1-associated protein 2-like 1
• NCBI Official Symbol: BAIAP2L1
• NCBI Official Synonym Symbols: IRTKS
• NCBI Protein Information: brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; BAI1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate
• UniProt Protein Name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
• Protein Family: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein
• UniProt Gene Name: BAIAP2L1
• UniProt Synonym Gene Names: IRTKS; BAI1-associated protein 2-like protein 1
• UniProt Entry Name: BI2L1_HUMAN

NCBI Description

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

Uniprot Description

IRTKS: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: regulation of insulin receptor signaling pathway; response to bacterium; plasma membrane organization and biogenesis; positive regulation of actin filament polymerization