Rabbit anti-Human BAIAP2L1 Polyclonal Antibody | anti-BAIAP2L1 antibody

BAIAP2L1 Antibody

Cat. Num. AAA9408131

• Gene Names: BAIAP2L1; IRTKS
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: BAIAP2L1; Polyclonal Antibody; BAIAP2L1 Antibody; BI2L1; anti-BAIAP2L1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total BAIAP2L1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 511

• Applicable Applications for anti-BAIAP2L1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human BAIAP2L1.
• Target Name: BAIAP2L1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from HepG2 cells, using BAIAP2L1 antibody.)

Related Product Information for anti-BAIAP2L1 antibody

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).Hillier L.W., Nature 424:157-164(2003).Scherer S.W., Science 300:767-772(2003).

Product Categories/Family for anti-BAIAP2L1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 32171238
• NCBI GeneID: 55971
• NCBI Accession #: NP_061330.2
• NCBI GenBank Nucleotide #: NM_018842.4
• UniProt Accession #: Q9UHR4; Q75L21; Q75L22; Q96CV4; Q9H5F5; Q9Y2M8; A4D268
• Molecular Weight: 56,883 Da
• NCBI Official Full Name: brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
• NCBI Official Synonym Full Names: BAI1-associated protein 2-like 1
• NCBI Official Symbol: BAIAP2L1
• NCBI Official Synonym Symbols: IRTKS
• NCBI Protein Information: brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
• UniProt Protein Name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
• Protein Family: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein
• UniProt Gene Name: BAIAP2L1
• UniProt Synonym Gene Names: IRTKS; BAI1-associated protein 2-like protein 1
• UniProt Entry Name: BI2L1_HUMAN

NCBI Description

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

Uniprot Description

IRTKS: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: regulation of insulin receptor signaling pathway; positive regulation of actin filament polymerization; response to bacterium; plasma membrane organization and biogenesis