Rabbit anti-Human BAI3 Polyclonal Antibody | anti-BAI3 antibody

BAI3, CT (Brain-specific Angiogenesis Inhibitor 3, KIAA0550)

Cat. Num. AAA630312

• Gene Names: BAI3; KIAA0550; MGC133100
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: BAI3; Polyclonal Antibody; CT (Brain-specific Angiogenesis Inhibitor 3; KIAA0550); Anti -BAI3; anti-BAI3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BAI3.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-BAI3 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human BAI3 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-BAI3 antibody

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.

Product Categories/Family for anti-BAI3 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 4502359
• NCBI GeneID: 577
• NCBI Accession #: NP_001695.1
• NCBI GenBank Nucleotide #: NM_001704.2
• UniProt Accession #: O60242; O60297; Q2NKN6; Q5VY37; Q9BX54
• Molecular Weight: 171,518 Da
• NCBI Official Full Name: brain-specific angiogenesis inhibitor 3
• NCBI Official Synonym Full Names: brain-specific angiogenesis inhibitor 3
• NCBI Official Symbol: BAI3
• NCBI Official Synonym Symbols: KIAA0550; MGC133100
• NCBI Protein Information: brain-specific angiogenesis inhibitor 3; OTTHUMP00000016691; dJ91B17.1 (brain-specific angiogenesis inhibitor 3)
• UniProt Protein Name: Brain-specific angiogenesis inhibitor 3
• UniProt Gene Name: BAI3
• UniProt Synonym Gene Names: KIAA0550
• UniProt Entry Name: BAI3_HUMAN

NCBI Description

This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq]

Uniprot Description

BAI3: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q12

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis