Rabbit anti-Human BACE1 Polyclonal Antibody | anti-BACE1 antibody
BACE1 antibody
Gene Names
Bace1; C76936
Reactivity
Human
Applications
Immunohistochemistry
Purity
BACE1 antibody was purified by affinity chromatography.
Synonyms
BACE1; Polyclonal Antibody; BACE1 antibody; Polyclonal BACE1; Anti-BACE1; bace; b-Secretase; BACE 1; BACE -1; asp2; bace1; beta-secretase; aspartylprotease 2; beta-site amyloid precursor protein cleaving enzyme; APP beta-secretase; beta-site app cleaving enzyme; anti-BACE1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Human
Purity/Purification
BACE1 antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
501
Applicable Applications for anti-BACE1 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes
IHC-P: 2.5-3 ug/ml
Biological Significance
Beta-secretase 1 (BACE1) is an enzyme that in humans is encoded by the BACE1 gene. Beta-Secretase is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
BACE1 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-BACE1 antibody
Rabbit polyclonal BACE1 antibody
Product Categories/Family for anti-BACE1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,748 Da
NCBI Official Full Name
beta-secretase 1 isoform 1
NCBI Official Synonym Full Names
beta-site APP cleaving enzyme 1
NCBI Official Symbol
Bace1
NCBI Official Synonym Symbols
C76936
NCBI Protein Information
beta-secretase 1
UniProt Protein Name
Beta-secretase 1
Protein Family
UniProt Gene Name
Bace1
UniProt Synonym Gene Names
Bace; ASP2; Asp 2; Beta-site APP cleaving enzyme 1
UniProt Entry Name
BACE1_MOUSE
Uniprot Description
BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described.
Protein type: EC 3.4.23.46; Protease; Membrane protein, integral
Cellular Component: Golgi apparatus; multivesicular body; membrane; axon; endoplasmic reticulum; integral to plasma membrane; late endosome; plasma membrane; integral to membrane; trans-Golgi network; cytoplasmic vesicle; endosome
Molecular Function: peptidase activity; protein binding; enzyme binding; hydrolase activity; beta-amyloid binding; endopeptidase activity; aspartic-type endopeptidase activity
Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; proteolysis
Research Articles on BACE1
Similar Products
Product Notes
The BACE1 bace1 (Catalog #AAA535570) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BACE1 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BACE1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin. IHC-P: 2.5-3 ug/ml. Researchers should empirically determine the suitability of the BACE1 bace1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BACE1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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