Western Blot (WB)
(The anti-Phospho-BACE-S498 Pab is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate)
Rabbit anti-Human BACE Polyclonal Antibody
BACE, phosphorylated (Ser498) (Beta-secretase 1, Beta-site APP Cleaving Enzyme 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Aspartyl Protease 2, Asp 2, ASP2, Membrane-associated Aspartic Protease 2, Memapsin-2, BACE1, BACE, KIAA1149)
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
BACE; Polyclonal Antibody; phosphorylated (Ser498) (Beta-secretase 1; Beta-site APP Cleaving Enzyme 1; Beta-site Amyloid Precursor Protein Cleaving Enzyme 1; Aspartyl Protease 2; Asp 2; ASP2; Membrane-associated Aspartic Protease 2; Memapsin-2; BACE1; KIAA1149); Anti -BACE; anti-BACE antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human BACE when phosphorylated at Ser498.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Applicable Applications for anti-BACE antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Immunogen
Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser498 of human BACE (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(The anti-Phospho-BACE-S498 Pab is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate)
Western Blot (WB)
(The anti-Phospho-BACE-S498 Pab is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Related Product Information for anti-BACE antibody
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Product Categories/Family for anti-BACE antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
BacE
Protein Family
Similar Products
Product Notes
The BACE (Catalog #AAA630050) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BACE, phosphorylated (Ser498) (Beta-secretase 1, Beta-site APP Cleaving Enzyme 1, Beta-site Amyloid Precursor Protein Cleaving Enzyme 1, Aspartyl Protease 2, Asp 2, ASP2, Membrane-associated Aspartic Protease 2, Memapsin-2, BACE1, BACE, KIAA1149) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BACE can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the BACE for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BACE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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