Rabbit anti-Human Axl Polyclonal Antibody | anti-Axl antibody

Axl, NT (Axl, Ark, Ufo, Tyrosine-protein kinase receptor UFO, Adhesion-related kinase) (PE)

Cat. Num. AAA6277040

• Gene Names: Axl; Ark; Ufo; Tyro7; AI323647
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: Axl; Polyclonal Antibody; NT (Axl; Ark; Ufo; Tyrosine-protein kinase receptor UFO; Adhesion-related kinase) (PE); Adhesion-related kinase; anti-Axl antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes Axl. Species crossreactivity: human
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-Axl antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 122-149 in the N-terminal region of mouse Axl, Swiss/UniProt Accession: Q00993.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in K562 cell line lysates (35ug/lane) usingMBS6010370.This demonstrates that MBS6010370 detected the Axl protein (arrow).)

Related Product Information for anti-Axl antibody

Axl may function as a signal transducer between specific cell types of mesodermal origin.

Product Categories/Family for anti-Axl antibody

Antibodies; Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 342187104
• NCBI GeneID: 26362
• UniProt Accession #: Q00993; Q80YQ3
• Molecular Weight: 98,191 Da
• NCBI Official Full Name: Tyrosine-protein kinase receptor UFO
• NCBI Official Synonym Full Names: AXL receptor tyrosine kinase
• NCBI Official Symbol: Axl
• NCBI Official Synonym Symbols: Ark; Ufo; Tyro7; AI323647
• NCBI Protein Information: tyrosine-protein kinase receptor UFO; ufo oncogene homolog; adhesion-related kinase
• UniProt Protein Name: Tyrosine-protein kinase receptor UFO
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: Axl
• UniProt Synonym Gene Names: Ark; Ufo
• UniProt Entry Name: UFO_MOUSE

Uniprot Description

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family

Cellular Component: extracellular space; cell surface; membrane; cell; integral to membrane; plasma membrane; intracellular

Molecular Function: transferase activity; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phosphoinositide 3-kinase binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; neuron migration; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; negative regulation of neuron apoptosis; inflammatory response; cell differentiation; secretion by cell; forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; immune system process; vagina development; negative regulation of tumor necrosis factor production; phagocytosis; positive regulation of protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; spermatogenesis; blood vessel remodeling; positive regulation of cytokine and chemokine mediated signaling pathway; phosphorylation; apoptotic cell clearance; negative regulation of apoptosis