Western Blot (WB)
(AXIN1 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AXIN1 antibody detected the AXIN1 protein (arrow).)
Rabbit AXIN1 Polyclonal Antibody | anti-AXIN1 antibody
AXIN1 Antibody (Center)
Western Blot (WB)
(AXIN1 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AXIN1 antibody detected the AXIN1 protein (arrow).)
Western Blot (WB)
(AXIN1 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AXIN1 antibody detected the AXIN1 protein (arrow).)
regulation of G-protein signaling (RGS) domain and a dishevelled
and axin (DIX) domain. The encoded protein interacts with
adenomatosis polyposis coli, catenin beta-1, glycogen synthase
kinase 3 beta, protein phosphate 2, and itself. This protein
functions as a negative regulator of the wingless-type MMTV
integration site family, member 1 (WNT) signaling pathway and can
induce apoptosis. The crystal structure of a portion of this
protein, alone and in a complex with other proteins, has been
resolved. Mutations in this gene have been associated with
hepatocellular carcinoma, hepatoblastomas, ovarian endometriod
adenocarcinomas, and medullablastomas. Two transcript variants
encoding distinct isoforms have been identified for this gene.
Yang, L.H., et al. Mol. Cancer 9, 25 (2010) :
Wooten, E.C., et al. PLoS ONE 5 (1), E8830 (2010) :
Kameoka, M., et al. AIDS Res. Hum. Retroviruses 25(10):1005-1011(2009)
Li, Q., et al. Nat. Cell Biol. 11(9):1128-1134(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Uniprot Description
axin 1: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin-1 functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Wild-type axin 1 can induce apoptosis in hepatocellular and colorectal cancer cells. Is downregulated during progression of esophageal squamous cell carcinoma. Mutation of the axin-1 gene is associated with hepatocellular carcinoma, anaplastic thyroid cancer, medulloblastoma and colorectal cancer. May have a role in oncogenesis in Hodgkin lymphoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.
Protein type: Adaptor/scaffold; Tumor suppressor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: Golgi apparatus; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; postsynaptic density; cytoplasmic membrane-bound vesicle; cell cortex; cytoplasmic vesicle; nucleus; beta-catenin destruction complex; cytosol; lateral plasma membrane
Molecular Function: protein C-terminus binding; identical protein binding; protein homodimerization activity; protein self-association; p53 binding; beta-catenin binding; protein kinase binding; GTPase activator activity; signal transducer activity; protein binding; receptor signaling complex scaffold activity; enzyme binding; ubiquitin protein ligase binding; protein complex scaffold; SMAD binding; receptor binding
Biological Process: cell death; negative regulation of Wnt receptor signaling pathway; protein polyubiquitination; embryonic eye morphogenesis; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; dorsal/ventral axis specification; negative regulation of protein metabolic process; nucleocytoplasmic transport; Wnt receptor signaling pathway through beta-catenin; olfactory placode formation; cytoplasmic microtubule organization and biogenesis; activation of JNK activity; sensory perception of sound; positive regulation of ubiquitin-protein ligase activity; Wnt receptor signaling pathway involved in forebrain neuron fate commitment; protein catabolic process; protein homooligomerization; axial mesoderm formation; in utero embryonic development; muscle cell development; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; optic placode formation; positive regulation of peptidyl-serine phosphorylation; cellular protein complex assembly; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; forebrain anterior/posterior pattern formation; activation of protein kinase activity; positive regulation of protein catabolic process; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; positive regulation of GTPase activity
Disease: Caudal Duplication Anomaly; Hepatocellular Carcinoma
Research Articles on AXIN1
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Product Notes
The AXIN1 axin1 (Catalog #AAA9211328) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 330-359. The AXIN1 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's AXIN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AXIN1 axin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AXIN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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