SDS-Page
(Recombinant KAT7 protein gel. Recombinant KAT7 was run on a 10% SDS-PAGE gel and stained with Coomassie blue. Mw: 67 kDa Purity: >85%)
KAT7 recombinant protein
Recombinant KAT7 protein
Shipping Temp: Dry Ice
SDS-Page
(Recombinant KAT7 protein gel. Recombinant KAT7 was run on a 10% SDS-PAGE gel and stained with Coomassie blue. Mw: 67 kDa Purity: >85%)
SDS-Page
(Recombinant KAT7 protein gel. Recombinant KAT7 was run on a 10% SDS-PAGE gel and stained with Coomassie blue. Mw: 67 kDa Purity: >85%)
Western Blot (WB)
(Recombinant KAT7 protein activity assay 0.5 ug Histone H4 was incubated with 0 ug (-), 0.4 ug (+) KAT7 in 20 ul reaction system for 2 hours at room temperature. Half of each reaction was run on a 13% SDS-PAGE gel, and products were detected by Western blot. H4ac (pan-acetyl) antibody was used to recognize acetylated histone H4.)
Western Blot (WB)
(Recombinant KAT7 protein activity assay 0.5 ug Histone H4 was incubated with 0 ug (-), 0.4 ug (+) KAT7 in 20 ul reaction system for 2 hours at room temperature. Half of each reaction was run on a 13% SDS-PAGE gel, and products were detected by Western blot. H4ac (pan-acetyl) antibody was used to recognize acetylated histone H4.)
Background: KAT7 (K(Lysine) Acetyltransferase 7) is a MYST-family histone acetyltransferase (HAT) that forms a complex with ING4/5, JADE1/2/3, and Eaf6, which is found enriched on coding regions of genes, supporting a role in transcriptional elongation. In addition, KAT7 is thought to participate in events controlling the initiation of DNA replication.
NCBI and Uniprot Product Information
Uniprot Description
MYST2: a histone acetyltransferase that participates in DNA replication and the loading of the minichromosome maintenance (Mcm) complex onto chromatin. Is required for origin recognition complex (Orc) formation and replication licensing, and is responsible for much of the acetylation of histone H4. Interacts with MCM2 and ORC1L. Phosphorylated by Cdc2 during mitosis, creating a site that recruits Plk1, which in turn phosphorylates MYST2. Its phosphorylation by Plk1 during mitosis may be required for the formation of the prereplicative complex. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. Specifically represses AR-mediated transcription.
Protein type: EC 2.3.1.48; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: nucleoplasm; cytoplasm; nucleolus; histone acetyltransferase complex
Molecular Function: protein binding; histone acetyltransferase activity; zinc ion binding; transcription factor activity
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA replication
Research Articles on KAT7
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Product Notes
The KAT7 kat7 (Catalog #AAA388200) is a Recombinant Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KAT7, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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