Rabbit anti-Human AVPR1B Polyclonal Antibody | anti-AVPR1B antibody

AVPR1B, CT (AVPR1B, AVPR3, VPR3, Vasopressin V1b receptor, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor) (APC)

Cat. Num. AAA6276965

• Gene Names: AVPR1B; AVPR3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: AVPR1B; Polyclonal Antibody; CT (AVPR1B; AVPR3; VPR3; Vasopressin V1b receptor; AVPR V1b; AVPR V3; Antidiuretic hormone receptor 1b; Vasopressin V3 receptor) (APC); Vasopressin V3 receptor; anti-AVPR1B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human AVPR1B.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-AVPR1B antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 289-317 in the C-terminal region of human AVPR1B, Swiss/UniProt Accession: P47901
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in K562 cell line lysates (35ug/lane) usingMBS6002725. This demonstrates that MBS6002725 detected the AVPR1B protein (arrow).)

Testing Data

(All lanes: MBS6002725 (1:1000) Lane 1: HUVEC whole cell lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20ug/lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 47kD. Blocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-AVPR1B antibody

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.

Product Categories/Family for anti-AVPR1B antibody

Antibodies; Receptors

References

1. van West, D., et al. Psychiatry Res 179(1):64-68(2010). 2. Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010). 3. Bosker, F.J., et al. Mol. Psychiatry (2010). In press: 4. van West, D., et al. Psychiatr. Genet. 19(2):102-103(2009). 5. Tabakoff, B., et al. BMC Biol. 7, 70 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4502333
• NCBI GeneID: 553
• NCBI Accession #: NP_000698.1
• NCBI GenBank Nucleotide #: NM_000707.3
• UniProt Accession #: P47901; Q5TZ00; B0M0J6
• Molecular Weight: 46,971 Da
• NCBI Official Full Name: vasopressin V1b receptor
• NCBI Official Synonym Full Names: arginine vasopressin receptor 1B
• NCBI Official Symbol: AVPR1B
• NCBI Official Synonym Symbols: AVPR3
• NCBI Protein Information: vasopressin V1b receptor; V1bR; AVPR V3; AVPR V1b; vasopressin V3 receptor; arginine vasopressin receptor 3; antidiuretic hormone receptor 1B; pituitary vasopressin receptor 3
• UniProt Protein Name: Vasopressin V1b receptor
• Protein Family: Vasopressin V1b receptor
• UniProt Gene Name: AVPR1B
• UniProt Synonym Gene Names: AVPR3; VPR3; V1bR
• UniProt Entry Name: V1BR_HUMAN

NCBI Description

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

Uniprot Description

AVPR1B: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: integral to plasma membrane; plasma membrane; endosome

Molecular Function: protein kinase C binding; peptide binding; vasopressin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; regulation of systemic arterial blood pressure by vasopressin; phospholipase C activation; positive regulation of vasoconstriction; cellular response to hormone stimulus