Rabbit HOOK3 Polyclonal Antibody | anti-HOOK3 antibody

HOOK3 Polyclonal Antibody

Cat. Num. AAA3010586

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: HOOK3; Polyclonal Antibody; HOOK3 Polyclonal Antibody; HK3; anti-HOOK3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: HOOK3 polyclonal antibody detects endogenous levels of HOOK3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 718

• Applicable Applications for anti-HOOK3 antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:2000
• Immunogen: Recombinant protein of human HOOK3
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using HOOK3 antibody.)

Related Product Information for anti-HOOK3 antibody

Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity.

NCBI and Uniprot Product Information

• NCBI GI #: 14165274
• NCBI Accession #: NP_115786
• NCBI GenBank Nucleotide #: NP_115786.1
• UniProt Accession #: Q86VS8
• Molecular Weight: ~ 170kDa
• NCBI Official Full Name: protein Hook homolog 3
• UniProt Protein Name: Protein Hook homolog 3
• Protein Family: Protein Hook
• UniProt Gene Name: HOOK3
• UniProt Synonym Gene Names: h-hook3; hHK3
• UniProt Entry Name: HOOK3_HUMAN

Uniprot Description

HOOK3: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Belongs to the hook family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: centrosome; cis-Golgi network; cytoplasm; cytosol; Golgi apparatus; microtubule; microtubule organizing center; pericentriolar material

Molecular Function: identical protein binding; microtubule binding; protein binding

Biological Process: cytoplasmic microtubule organization and biogenesis; early endosome to late endosome transport; endosome organization and biogenesis; endosome to lysosome transport; Golgi localization; interkinetic nuclear migration; lysosome organization and biogenesis; negative regulation of neurogenesis; protein transport