Rabbit anti-Virus Avian Influenza Neuraminidase Polyclonal Antibody | anti-NA antibody

Avian Influenza Neuraminidase Antibody

Cat. Num. AAA150893

• Reactivity: Virus
• Applications: ELISA
• Purity: Avian Influenza Neuraminidase Antibody is affinity chromatography purified via peptide column.
• Synonyms: Avian Influenza Neuraminidase; Polyclonal Antibody; Avian Influenza Neuraminidase Antibody; Neuraminidase; anti-NA antibody

• Host: Rabbit
• Reactivity: Virus
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Avian Influenza Neuraminidase Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 469

• Applicable Applications for anti-NA antibody: ELISA (EIA)
• Application Notes: Avian influenza neuraminidase antibody can be used for the detection of the avian influenza neuraminidase protein from the H5N1 strain of Avian influenza A in ELISA. It will detect 10 ng of free peptide at 1 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Avian influenza neuraminidase antibody was raised against a synthetic peptide corresponding to 15 amino acids at the carboxy terminus of the avian influenza neuraminidase protein. Efforts were made to use relatively conserved regions as the antigen.
• Buffer: Avian Influenza Neuraminidase Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Avian Influenza Neuraminidase antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Related Product Information for anti-NA antibody

Avian Influenza Neuraminidase Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the NA protein also contributes to the high virulence of the H5N1 virus.

NCBI and Uniprot Product Information

• NCBI GI #: 39840718
• UniProt Accession #: Q710U6; Q0A2H3
• Molecular Weight: 51,486 Da
• NCBI Official Full Name: neuraminidase
• UniProt Protein Name: Neuraminidase
• Protein Family: Neuraminidase
• UniProt Gene Name: NA
• UniProt Entry Name: NRAM_I59A0

Uniprot Description

Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.