Rabbit anti-Virus Influenza Hemagglutinin 4 Polyclonal Antibody | anti-HA antibody

Avian Influenza Hemagglutinin 4 Antibody

Cat. Num. AAA9404916

• Reactivity: Virus
• Applications: ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Influenza Hemagglutinin 4; Polyclonal Antibody; Avian Influenza Hemagglutinin 4 Antibody; Avian Influenza Hemagglutinin 4; AFHA-4; Avian flu hemagglutinin; Avian influenza H5; anti-HA antibody

• Host: Rabbit
• Reactivity: Virus
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 568

• Applicable Applications for anti-HA antibody: ELISA (EIA)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a synthetic peptide corresponding to 10 amino acids near the center of the Hemagglutinin protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
• Target Name: Avian Influenza Hemagglutinin 4
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of (A) 5 ng and (B) 25 ng of recombinant HA1 with Avian Influenza Hemagglutinin 4 antibody at 1 ug/mL.)

Testing Data

(Hemagglutinin antibody at 1 ug/mL specifically recognizes Avian H5N1 influenza virus but not seasonal influenza virus A H1N1 Hemagglutinin protein.)

Related Product Information for anti-HA antibody

Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.

Product Categories/Family for anti-HA antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 50365729
• Molecular Weight: 64,262 Da
• NCBI Official Full Name: hemagglutinin
• UniProt Protein Name: Hemagglutinin
• Protein Family: Protein
• UniProt Gene Name: HA
• UniProt Entry Name: Q692M2_9INFA

Uniprot Description

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.