Western Blot (WB)
(ATP8A2 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ATP8A2 antibody detected the ATP8A2 protein (arrow).)
Rabbit anti-Human ATP8A2 Polyclonal Antibody | anti-ATP8A2 antibody
ATP8A2 Antibody (N-term)
Western Blot (WB)
(ATP8A2 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ATP8A2 antibody detected the ATP8A2 protein (arrow).)
Western Blot (WB)
(ATP8A2 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ATP8A2 antibody detected the ATP8A2 protein (arrow).)
Flow Cytometry (FC/FACS)
(ATP8A2 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(ATP8A2 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Coleman, J.A., et al. J. Biol. Chem. 284(47):32670-32679(2009)
Dunham, A., et al. Nature 428(6982):522-528(2004)
Halleck, M.S., et al. Physiol. Genomics 1(3):139-150(1999)
Sun, X.L., et al. Gene Expr. 8(2):129-139(1999)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ). In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Uniprot Description
ATP8A2 iso1: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Hydrolase; Cell cycle regulation; Transporter; EC 3.6.3.1
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: Golgi apparatus; photoreceptor outer segment; integral to membrane; plasma membrane; endosome
Molecular Function: phospholipid-translocating ATPase activity; magnesium ion binding; ATP binding
Biological Process: skin development; inner ear morphogenesis; eating behavior; metabolic process; involuntary skeletal muscle contraction; positive regulation of multicellular organism growth; phospholipid translocation; negative regulation of cell proliferation; neuromuscular process controlling posture; axonogenesis; neurofilament cytoskeleton organization and biogenesis; neuron development; detection of light stimulus involved in visual perception; aging
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 4
Research Articles on ATP8A2
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Product Notes
The ATP8A2 atp8a2 (Catalog #AAA9201136) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 293-322. The ATP8A2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ATP8A2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the ATP8A2 atp8a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATP8A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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